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Learning Interpretable Regularized Ordinal Models from 3D Mesh Data for Neurodegenerative Disease Staging

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Publication date6/10/2022
Host publicationMachine Learning in Clinical Neuroimaging - 5th International Workshop, MLCN 2022, Held in Conjunction with MICCAI 2022, Proceedings
EditorsAhmed Abdulkadir, Deepti R. Bathula, Nicha C. Dvornek, Mohamad Habes, Seyed Mostafa Kia, Vinod Kumar, Thomas Wolfers
PublisherSpringer Science and Business Media Deutschland GmbH
Pages115-124
Number of pages10
ISBN (electronic)9783031178993
ISBN (print)9783031178986
<mark>Original language</mark>English
Event5th International Workshop on Machine Learning in Clinical Neuroimaging, MLCN 2022, held in Conjunction with the 25th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2022 - Singapore, Singapore
Duration: 18/09/202218/09/2022

Conference

Conference5th International Workshop on Machine Learning in Clinical Neuroimaging, MLCN 2022, held in Conjunction with the 25th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2022
Country/TerritorySingapore
CitySingapore
Period18/09/2218/09/22

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume13596 LNCS
ISSN (Print)0302-9743
ISSN (electronic)1611-3349

Conference

Conference5th International Workshop on Machine Learning in Clinical Neuroimaging, MLCN 2022, held in Conjunction with the 25th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2022
Country/TerritorySingapore
CitySingapore
Period18/09/2218/09/22

Abstract

We extend the sparse, spatially piecewise-contiguous linear classification framework for mesh-based data to ordinal logistic regression. The algorithm is intended for use with subcortical shape and cortical thickness data where progressive clinical staging is available, as is generally the case in neurodegenerative diseases. We apply the tool to Parkinson’s and Alzheimer’s disease staging. The resulting biomarkers predict Hoehn-Yahr and cognitive impairment stages at competitive accuracy; the models remain parsimonious and outperform one-against-all models in terms of the Akaike and Bayesian information criteria.