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Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array

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Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array. / Rodriguez, Santiago; Gaunt, Tom R.; Guo, Yiran et al.
In: European Journal of Human Genetics, Vol. 24, No. 1, 01.2016, p. 106-112.

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Harvard

Rodriguez, S, Gaunt, TR, Guo, Y, Zheng, J, Barnes, MR, Tang, W, Danish, F, Johnson, A, Castillo, BA, Li, YR, Hakonarson, H, Buxbaum, SG, Palmer, T, Tsai, MY, Lange, LA, Ebrahim, S, Davey Smith, G, Lawlor, DA, Folsom, AR, Hoogeveen, R, Reiner, A, Keating, B & Day, IN 2016, 'Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array', European Journal of Human Genetics, vol. 24, no. 1, pp. 106-112. https://doi.org/10.1038/ejhg.2015.63

APA

Rodriguez, S., Gaunt, T. R., Guo, Y., Zheng, J., Barnes, M. R., Tang, W., Danish, F., Johnson, A., Castillo, B. A., Li, Y. R., Hakonarson, H., Buxbaum, S. G., Palmer, T., Tsai, M. Y., Lange, L. A., Ebrahim, S., Davey Smith, G., Lawlor, D. A., Folsom, A. R., ... Day, I. N. (2016). Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array. European Journal of Human Genetics, 24(1), 106-112. https://doi.org/10.1038/ejhg.2015.63

Vancouver

Rodriguez S, Gaunt TR, Guo Y, Zheng J, Barnes MR, Tang W et al. Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array. European Journal of Human Genetics. 2016 Jan;24(1):106-112. Epub 2015 Apr 29. doi: 10.1038/ejhg.2015.63

Author

Rodriguez, Santiago ; Gaunt, Tom R. ; Guo, Yiran et al. / Lipids, obesity and gallbladder disease in women : insights from genetic studies using the cardiovascular gene-centric 50K SNP array. In: European Journal of Human Genetics. 2016 ; Vol. 24, No. 1. pp. 106-112.

Bibtex

@article{47060b2fafda47928781ce59ad54f9b5,
title = "Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array",
abstract = "Gallbladder disease (GBD) has an overall prevalence of 10-40% depending on factors such as age, gender, population, obesity and diabetes, and represents a major economic burden. Although gallstones are composed of cholesterol by-products and are associated with obesity, presumed causal pathways remain unproven, although BMI reduction is typically recommended. We performed genetic studies to discover candidate genes and define pathways involved in GBD. We genotyped 15 241 women of European ancestry from three cohorts, including 3216 with GBD, using the Human cardiovascular disease (HumanCVD) BeadChip containing up to ~53 000 single-nucleotide polymorphisms (SNPs). Effect sizes with P-values for development of GBD were generated. We identify two new loci associated with GBD, GCKR rs1260326:T>C (P=5.88 × 10(-7), {\ss}=-0.146) and TTC39B rs686030:C>A (P=6.95x10(-7), {\ss}=0.271) and detect four independent SNP effects in ABCG8 rs4953023:G>A (P=7.41 × 10(-47), {\ss}=0.734), ABCG8 rs4299376:G(>)T (P=2.40 × 10(-18), {\ss}=0.278), ABCG5 rs6544718:T>C (P=2.08 × 10(-14), {\ss}=0.044) and ABCG5 rs6720173:G>C (P=3.81 × 10(-12), {\ss}(=)0.262) in conditional analyses taking genotypes of rs4953023:G>A as a covariate. We also delineate the risk effects among many genotypes known to influence lipids. These data, from the largest GBD genetic study to date, show that specific, mainly hepatocyte-centred, components of lipid metabolism are important to GBD risk in women. We discuss the potential pharmaceutical implications of our findings.European Journal of Human Genetics advance online publication, 29 April 2015; doi:10.1038/ejhg.2015.63.",
author = "Santiago Rodriguez and Gaunt, {Tom R.} and Yiran Guo and Jie Zheng and Barnes, {Michael R.} and Weihang Tang and Fazal Danish and Andrew Johnson and Castillo, {Berta A.} and Li, {Yun R.} and Hakon Hakonarson and Buxbaum, {Sarah G.} and Tom Palmer and Tsai, {Michael Y.} and Lange, {Leslie A.} and Shah Ebrahim and {Davey Smith}, George and Lawlor, {Debbie A.} and Folsom, {Aaron R.} and Ron Hoogeveen and Alex Reiner and Brendan Keating and Day, {Ian Nm}",
year = "2016",
month = jan,
doi = "10.1038/ejhg.2015.63",
language = "English",
volume = "24",
pages = "106--112",
journal = "European Journal of Human Genetics",
issn = "1018-4813",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Lipids, obesity and gallbladder disease in women

T2 - insights from genetic studies using the cardiovascular gene-centric 50K SNP array

AU - Rodriguez, Santiago

AU - Gaunt, Tom R.

AU - Guo, Yiran

AU - Zheng, Jie

AU - Barnes, Michael R.

AU - Tang, Weihang

AU - Danish, Fazal

AU - Johnson, Andrew

AU - Castillo, Berta A.

AU - Li, Yun R.

AU - Hakonarson, Hakon

AU - Buxbaum, Sarah G.

AU - Palmer, Tom

AU - Tsai, Michael Y.

AU - Lange, Leslie A.

AU - Ebrahim, Shah

AU - Davey Smith, George

AU - Lawlor, Debbie A.

AU - Folsom, Aaron R.

AU - Hoogeveen, Ron

AU - Reiner, Alex

AU - Keating, Brendan

AU - Day, Ian Nm

PY - 2016/1

Y1 - 2016/1

N2 - Gallbladder disease (GBD) has an overall prevalence of 10-40% depending on factors such as age, gender, population, obesity and diabetes, and represents a major economic burden. Although gallstones are composed of cholesterol by-products and are associated with obesity, presumed causal pathways remain unproven, although BMI reduction is typically recommended. We performed genetic studies to discover candidate genes and define pathways involved in GBD. We genotyped 15 241 women of European ancestry from three cohorts, including 3216 with GBD, using the Human cardiovascular disease (HumanCVD) BeadChip containing up to ~53 000 single-nucleotide polymorphisms (SNPs). Effect sizes with P-values for development of GBD were generated. We identify two new loci associated with GBD, GCKR rs1260326:T>C (P=5.88 × 10(-7), ß=-0.146) and TTC39B rs686030:C>A (P=6.95x10(-7), ß=0.271) and detect four independent SNP effects in ABCG8 rs4953023:G>A (P=7.41 × 10(-47), ß=0.734), ABCG8 rs4299376:G(>)T (P=2.40 × 10(-18), ß=0.278), ABCG5 rs6544718:T>C (P=2.08 × 10(-14), ß=0.044) and ABCG5 rs6720173:G>C (P=3.81 × 10(-12), ß(=)0.262) in conditional analyses taking genotypes of rs4953023:G>A as a covariate. We also delineate the risk effects among many genotypes known to influence lipids. These data, from the largest GBD genetic study to date, show that specific, mainly hepatocyte-centred, components of lipid metabolism are important to GBD risk in women. We discuss the potential pharmaceutical implications of our findings.European Journal of Human Genetics advance online publication, 29 April 2015; doi:10.1038/ejhg.2015.63.

AB - Gallbladder disease (GBD) has an overall prevalence of 10-40% depending on factors such as age, gender, population, obesity and diabetes, and represents a major economic burden. Although gallstones are composed of cholesterol by-products and are associated with obesity, presumed causal pathways remain unproven, although BMI reduction is typically recommended. We performed genetic studies to discover candidate genes and define pathways involved in GBD. We genotyped 15 241 women of European ancestry from three cohorts, including 3216 with GBD, using the Human cardiovascular disease (HumanCVD) BeadChip containing up to ~53 000 single-nucleotide polymorphisms (SNPs). Effect sizes with P-values for development of GBD were generated. We identify two new loci associated with GBD, GCKR rs1260326:T>C (P=5.88 × 10(-7), ß=-0.146) and TTC39B rs686030:C>A (P=6.95x10(-7), ß=0.271) and detect four independent SNP effects in ABCG8 rs4953023:G>A (P=7.41 × 10(-47), ß=0.734), ABCG8 rs4299376:G(>)T (P=2.40 × 10(-18), ß=0.278), ABCG5 rs6544718:T>C (P=2.08 × 10(-14), ß=0.044) and ABCG5 rs6720173:G>C (P=3.81 × 10(-12), ß(=)0.262) in conditional analyses taking genotypes of rs4953023:G>A as a covariate. We also delineate the risk effects among many genotypes known to influence lipids. These data, from the largest GBD genetic study to date, show that specific, mainly hepatocyte-centred, components of lipid metabolism are important to GBD risk in women. We discuss the potential pharmaceutical implications of our findings.European Journal of Human Genetics advance online publication, 29 April 2015; doi:10.1038/ejhg.2015.63.

U2 - 10.1038/ejhg.2015.63

DO - 10.1038/ejhg.2015.63

M3 - Journal article

C2 - 25920552

VL - 24

SP - 106

EP - 112

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

SN - 1018-4813

IS - 1

ER -