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  • Minutti 2017 AAM pure

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Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver. / Minutti, Carlos M; Jackson-Jones, Lucy H; García-Fojeda, Belén et al.
In: Science, Vol. 356, No. 6342, 09.06.2017, p. 1076-1080.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Minutti, CM, Jackson-Jones, LH, García-Fojeda, B, Knipper, JA, Sutherland, TE, Logan, N, Ringqvist, E, Guillamat-Prats, R, Ferenbach, DA, Artigas, A, Stamme, C, Chroneos, ZC, Zaiss, DM, Casals, C & Allen, JE 2017, 'Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver', Science, vol. 356, no. 6342, pp. 1076-1080. https://doi.org/10.1126/science.aaj2067

APA

Minutti, C. M., Jackson-Jones, L. H., García-Fojeda, B., Knipper, J. A., Sutherland, T. E., Logan, N., Ringqvist, E., Guillamat-Prats, R., Ferenbach, D. A., Artigas, A., Stamme, C., Chroneos, Z. C., Zaiss, D. M., Casals, C., & Allen, J. E. (2017). Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver. Science, 356(6342), 1076-1080. https://doi.org/10.1126/science.aaj2067

Vancouver

Minutti CM, Jackson-Jones LH, García-Fojeda B, Knipper JA, Sutherland TE, Logan N et al. Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver. Science. 2017 Jun 9;356(6342):1076-1080. Epub 2017 May 11. doi: 10.1126/science.aaj2067

Author

Minutti, Carlos M ; Jackson-Jones, Lucy H ; García-Fojeda, Belén et al. / Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver. In: Science. 2017 ; Vol. 356, No. 6342. pp. 1076-1080.

Bibtex

@article{044996fb56c14554bf404cf7884e03c0,
title = "Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver",
abstract = "The type 2 immune response controls helminth infection and maintains tissue homeostasis but can lead to allergy and fibrosis if not adequately regulated. We have discovered local tissue-specific amplifiers of type 2-mediated macrophage activation. In the lung, surfactant protein A (SP-A) enhanced interleukin-4 (IL-4)-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury after infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair after bacterial infection, but resulted in fibrosis after peritoneal dialysis. IL-4 drives production of these structurally related defense collagens, SP-A and C1q, and the expression of their receptor, myosin 18A. These findings reveal the existence within different tissues of an amplification system needed for local type 2 responses.",
keywords = "Animals, Complement C1q, Humans, Interleukin-4, Listeria monocytogenes, Listeriosis, Liver, Lung, Macrophage Activation, Mice, Mice, Inbred C57BL, Nippostrongylus, Pulmonary Surfactant-Associated Protein A, Receptors, Interleukin-4, Regeneration, Strongylida Infections, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Minutti, {Carlos M} and Jackson-Jones, {Lucy H} and Bel{\'e}n Garc{\'i}a-Fojeda and Knipper, {Johanna A} and Sutherland, {Tara E} and Nicola Logan and Emma Ringqvist and Raquel Guillamat-Prats and Ferenbach, {David A} and Antonio Artigas and Cordula Stamme and Chroneos, {Zissis C} and Zaiss, {Dietmar M} and Cristina Casals and Allen, {Judith E}",
note = "Copyright {\textcopyright} 2017, American Association for the Advancement of Science.",
year = "2017",
month = jun,
day = "9",
doi = "10.1126/science.aaj2067",
language = "English",
volume = "356",
pages = "1076--1080",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6342",

}

RIS

TY - JOUR

T1 - Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver

AU - Minutti, Carlos M

AU - Jackson-Jones, Lucy H

AU - García-Fojeda, Belén

AU - Knipper, Johanna A

AU - Sutherland, Tara E

AU - Logan, Nicola

AU - Ringqvist, Emma

AU - Guillamat-Prats, Raquel

AU - Ferenbach, David A

AU - Artigas, Antonio

AU - Stamme, Cordula

AU - Chroneos, Zissis C

AU - Zaiss, Dietmar M

AU - Casals, Cristina

AU - Allen, Judith E

N1 - Copyright © 2017, American Association for the Advancement of Science.

PY - 2017/6/9

Y1 - 2017/6/9

N2 - The type 2 immune response controls helminth infection and maintains tissue homeostasis but can lead to allergy and fibrosis if not adequately regulated. We have discovered local tissue-specific amplifiers of type 2-mediated macrophage activation. In the lung, surfactant protein A (SP-A) enhanced interleukin-4 (IL-4)-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury after infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair after bacterial infection, but resulted in fibrosis after peritoneal dialysis. IL-4 drives production of these structurally related defense collagens, SP-A and C1q, and the expression of their receptor, myosin 18A. These findings reveal the existence within different tissues of an amplification system needed for local type 2 responses.

AB - The type 2 immune response controls helminth infection and maintains tissue homeostasis but can lead to allergy and fibrosis if not adequately regulated. We have discovered local tissue-specific amplifiers of type 2-mediated macrophage activation. In the lung, surfactant protein A (SP-A) enhanced interleukin-4 (IL-4)-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury after infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair after bacterial infection, but resulted in fibrosis after peritoneal dialysis. IL-4 drives production of these structurally related defense collagens, SP-A and C1q, and the expression of their receptor, myosin 18A. These findings reveal the existence within different tissues of an amplification system needed for local type 2 responses.

KW - Animals

KW - Complement C1q

KW - Humans

KW - Interleukin-4

KW - Listeria monocytogenes

KW - Listeriosis

KW - Liver

KW - Lung

KW - Macrophage Activation

KW - Mice

KW - Mice, Inbred C57BL

KW - Nippostrongylus

KW - Pulmonary Surfactant-Associated Protein A

KW - Receptors, Interleukin-4

KW - Regeneration

KW - Strongylida Infections

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1126/science.aaj2067

DO - 10.1126/science.aaj2067

M3 - Journal article

C2 - 28495878

VL - 356

SP - 1076

EP - 1080

JO - Science

JF - Science

SN - 0036-8075

IS - 6342

ER -