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Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest: the randomized CIRC trial

Research output: Contribution to journalJournal articlepeer-review

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  • Lars Wik
  • Jan-Aage Olsen
  • David Persse
  • Fritz Sterz
  • Michael Lozano Jr
  • Marc A. Brouwer
  • Mark Westfall
  • Chris Souders
  • Reinhard Malzer
  • Pierre M. van Grunsven
  • David Travis
  • Anne Whitehead
  • Ulrich R. Herken
  • E. Brooke Lerner
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<mark>Journal publication date</mark>06/2014
<mark>Journal</mark>Resuscitation
Issue number6
Volume85
Number of pages8
Pages (from-to)741-748
Publication StatusPublished
<mark>Original language</mark>English

Abstract

Objective: To compare integrated automated load distributing band CPR (iA-CPR) with high-quality manual CPR (M-CPR) to determine equivalence, superiority, or inferiority in survival to hospital discharge.
Methods: Between March 5, 2009 and January 11, 2011 a randomized, unblinded, controlled group sequential trial of adult out-of-hospital cardiac arrests of presumed cardiac origin was conducted at three US and two European sites. After EMS providers initiated manual compressions patients were randomized
to receive either iA-CPR or M-CPR. Patient follow-up was until all patients were discharged alive or died. The primary outcome, survival to hospital discharge, was analyzed adjusting for covariates, (age, witnessed arrest, initial cardiac rhythm, enrollment site) and interim analyses. CPR quality and protocol adherence were monitored (CPR fraction) electronically throughout the trial.
Results: Of 4753 randomized patients, 522 (11.0%) met post enrollment exclusion criteria. Therefore, 2099 (49.6%) received iA-CPR and 2132 (50.4%) M-CPR. Sustained ROSC (emergency department admittance), 24 h survival and hospital discharge (unknown for 12 cases) for iA-CPR compared to M-CPR were 600
(28.6%) vs. 689 (32.3%), 456 (21.8%) vs. 532 (25.0%), 196 (9.4%) vs. 233 (11.0%) patients, respectively. The adjusted odds ratio of survival to hospital discharge for iA-CPR compared to M-CPR, was 1.06 (95% CI 0.83–1.37), meeting the criteria for equivalence. The 20 min CPR fraction was 80.4% for iA-CPR and 80.2% for M-CPR.
Conclusion: Compared to high-quality M-CPR, iA-CPR resulted in statistically equivalent survival to hospital discharge.