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Maximum likelihood estimation of coalesce times in genealogical trees.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Maximum likelihood estimation of coalesce times in genealogical trees. / Meligkotsidou, Loukia; Fearnhead, Paul.
In: Genetics, Vol. 171, No. 4, 01.12.2005, p. 2073-2084.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Meligkotsidou, L & Fearnhead, P 2005, 'Maximum likelihood estimation of coalesce times in genealogical trees.', Genetics, vol. 171, no. 4, pp. 2073-2084. https://doi.org/10.1534/genetics.105.043067

APA

Meligkotsidou, L., & Fearnhead, P. (2005). Maximum likelihood estimation of coalesce times in genealogical trees. Genetics, 171(4), 2073-2084. https://doi.org/10.1534/genetics.105.043067

Vancouver

Meligkotsidou L, Fearnhead P. Maximum likelihood estimation of coalesce times in genealogical trees. Genetics. 2005 Dec 1;171(4):2073-2084. doi: 10.1534/genetics.105.043067

Author

Meligkotsidou, Loukia ; Fearnhead, Paul. / Maximum likelihood estimation of coalesce times in genealogical trees. In: Genetics. 2005 ; Vol. 171, No. 4. pp. 2073-2084.

Bibtex

@article{ac2b9608793243be9e462a6093842ec1,
title = "Maximum likelihood estimation of coalesce times in genealogical trees.",
abstract = "We develop a method for maximum-likelihood estimation of coalescence times in genealogical trees, based on population genetics data. For this purpose, a Viterbi-type algorithm is constructed to maximize the joint likelihood of the coalescence times. Marginal confidence intervals for the coalescence times based on the profile likelihoods are also computed. Our method of finding MLEs and calculating C.I.'s appears to be more accurate than alternative numerical maximization methods, and maximum-likelihood inference appears to be more accurate than other existing model-free approaches to estimating coalescent times. We demonstrate the method on two different data sets: human Y chromosome DNA data and fungus DNA data",
author = "Loukia Meligkotsidou and Paul Fearnhead",
note = "RAE_import_type : Journal article RAE_uoa_type : Statistics and Operational Research",
year = "2005",
month = dec,
day = "1",
doi = "10.1534/genetics.105.043067",
language = "English",
volume = "171",
pages = "2073--2084",
journal = "Genetics",
issn = "1943-2631",
publisher = "Genetics Society of America",
number = "4",

}

RIS

TY - JOUR

T1 - Maximum likelihood estimation of coalesce times in genealogical trees.

AU - Meligkotsidou, Loukia

AU - Fearnhead, Paul

N1 - RAE_import_type : Journal article RAE_uoa_type : Statistics and Operational Research

PY - 2005/12/1

Y1 - 2005/12/1

N2 - We develop a method for maximum-likelihood estimation of coalescence times in genealogical trees, based on population genetics data. For this purpose, a Viterbi-type algorithm is constructed to maximize the joint likelihood of the coalescence times. Marginal confidence intervals for the coalescence times based on the profile likelihoods are also computed. Our method of finding MLEs and calculating C.I.'s appears to be more accurate than alternative numerical maximization methods, and maximum-likelihood inference appears to be more accurate than other existing model-free approaches to estimating coalescent times. We demonstrate the method on two different data sets: human Y chromosome DNA data and fungus DNA data

AB - We develop a method for maximum-likelihood estimation of coalescence times in genealogical trees, based on population genetics data. For this purpose, a Viterbi-type algorithm is constructed to maximize the joint likelihood of the coalescence times. Marginal confidence intervals for the coalescence times based on the profile likelihoods are also computed. Our method of finding MLEs and calculating C.I.'s appears to be more accurate than alternative numerical maximization methods, and maximum-likelihood inference appears to be more accurate than other existing model-free approaches to estimating coalescent times. We demonstrate the method on two different data sets: human Y chromosome DNA data and fungus DNA data

U2 - 10.1534/genetics.105.043067

DO - 10.1534/genetics.105.043067

M3 - Journal article

VL - 171

SP - 2073

EP - 2084

JO - Genetics

JF - Genetics

SN - 1943-2631

IS - 4

ER -