Home > Research > Publications & Outputs > Mechanisms of oncogene-induced replication stress

Research

Links

Text available via DOI:

View graph of relations

Mechanisms of oncogene-induced replication stress: Jigsaw falling into place

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Mechanisms of oncogene-induced replication stress: Jigsaw falling into place. / Kotsantis, P.; Petermann, E.; Boulton, S.J.
In: Cancer Discovery, Vol. 8, No. 5, 30.04.2018, p. 537-555.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Kotsantis, P, Petermann, E & Boulton, SJ 2018, 'Mechanisms of oncogene-induced replication stress: Jigsaw falling into place', Cancer Discovery, vol. 8, no. 5, pp. 537-555. https://doi.org/10.1158/2159-8290.CD-17-1461

APA

Kotsantis, P., Petermann, E., & Boulton, S. J. (2018). Mechanisms of oncogene-induced replication stress: Jigsaw falling into place. Cancer Discovery, 8(5), 537-555. https://doi.org/10.1158/2159-8290.CD-17-1461

Vancouver

Kotsantis P, Petermann E, Boulton SJ. Mechanisms of oncogene-induced replication stress: Jigsaw falling into place. Cancer Discovery. 2018 Apr 30;8(5):537-555. doi: 10.1158/2159-8290.CD-17-1461

Author

Kotsantis, P. ; Petermann, E. ; Boulton, S.J. / Mechanisms of oncogene-induced replication stress : Jigsaw falling into place. In: Cancer Discovery. 2018 ; Vol. 8, No. 5. pp. 537-555.

Bibtex

@article{7f05cc962f744de0ac75cdef97b3707b,
title = "Mechanisms of oncogene-induced replication stress: Jigsaw falling into place",
abstract = "Oncogene activation disturbs cellular processes and accommodates a complex landscape of changes in the genome that contribute to genomic instability, which accelerates mutation rates and promotes tumorigenesis. Part of this cellular turmoil involves deregulation of physiologic DNA replication, widely described as replication stress. Oncogene-induced replication stress is an early driver of genomic instability and is attributed to a plethora of factors, most notably aberrant origin firing, replication–transcription collisions, reactive oxygen species, and defective nucleotide metabolism.Significance: Replication stress is a fundamental step and an early driver of tumorigenesis and has been associated with many activated oncogenes. Deciphering the mechanisms that contribute to the replication stress response may provide new avenues for targeted cancer treatment. In this review, we discuss the latest findings on the DNA replication stress response and examine the various mechanisms through which activated oncogenes induce replication stress.",
author = "P. Kotsantis and E. Petermann and S.J. Boulton",
year = "2018",
month = apr,
day = "30",
doi = "10.1158/2159-8290.CD-17-1461",
language = "English",
volume = "8",
pages = "537--555",
journal = "Cancer Discovery",
number = "5",

}

RIS

TY - JOUR

T1 - Mechanisms of oncogene-induced replication stress

T2 - Jigsaw falling into place

AU - Kotsantis, P.

AU - Petermann, E.

AU - Boulton, S.J.

PY - 2018/4/30

Y1 - 2018/4/30

N2 - Oncogene activation disturbs cellular processes and accommodates a complex landscape of changes in the genome that contribute to genomic instability, which accelerates mutation rates and promotes tumorigenesis. Part of this cellular turmoil involves deregulation of physiologic DNA replication, widely described as replication stress. Oncogene-induced replication stress is an early driver of genomic instability and is attributed to a plethora of factors, most notably aberrant origin firing, replication–transcription collisions, reactive oxygen species, and defective nucleotide metabolism.Significance: Replication stress is a fundamental step and an early driver of tumorigenesis and has been associated with many activated oncogenes. Deciphering the mechanisms that contribute to the replication stress response may provide new avenues for targeted cancer treatment. In this review, we discuss the latest findings on the DNA replication stress response and examine the various mechanisms through which activated oncogenes induce replication stress.

AB - Oncogene activation disturbs cellular processes and accommodates a complex landscape of changes in the genome that contribute to genomic instability, which accelerates mutation rates and promotes tumorigenesis. Part of this cellular turmoil involves deregulation of physiologic DNA replication, widely described as replication stress. Oncogene-induced replication stress is an early driver of genomic instability and is attributed to a plethora of factors, most notably aberrant origin firing, replication–transcription collisions, reactive oxygen species, and defective nucleotide metabolism.Significance: Replication stress is a fundamental step and an early driver of tumorigenesis and has been associated with many activated oncogenes. Deciphering the mechanisms that contribute to the replication stress response may provide new avenues for targeted cancer treatment. In this review, we discuss the latest findings on the DNA replication stress response and examine the various mechanisms through which activated oncogenes induce replication stress.

U2 - 10.1158/2159-8290.CD-17-1461

DO - 10.1158/2159-8290.CD-17-1461

M3 - Journal article

VL - 8

SP - 537

EP - 555

JO - Cancer Discovery

JF - Cancer Discovery

IS - 5

ER -