Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Membrane traffic in cytokinesis
AU - Matheson, J.
AU - Yu, X.
AU - Fielding, Andrew B.
AU - Gould, G. W.
PY - 2005/12
Y1 - 2005/12
N2 - A crucial facet of mammalian cell division is the separation of two daughter cells by a process known as cytokinesis. An early event in cytokinesis is the formation of an actomyosis contractile ring, which functions like a purse string in the constriction of the forming furrow between the cells. Far less well characterized are the membrane-trafficking steps which deliver new membrane to the cell surface during the plasma membrane expansion known to accompany furrow formation. It is now clearly established that the plasma membrane at the cleavage furrow of mammalian cells has a distinct lipid and protein composition from the rest of the plasma membrane. This may reflect a requirement for both increased surface area during furrowing and for the co-ordinated delivery of intracellular signalling or membrane re-modelling activities to the correct spatial coordinates during cleavage. In this review, we discuss recent work within the area of membrane traffic and cytokinesis.
AB - A crucial facet of mammalian cell division is the separation of two daughter cells by a process known as cytokinesis. An early event in cytokinesis is the formation of an actomyosis contractile ring, which functions like a purse string in the constriction of the forming furrow between the cells. Far less well characterized are the membrane-trafficking steps which deliver new membrane to the cell surface during the plasma membrane expansion known to accompany furrow formation. It is now clearly established that the plasma membrane at the cleavage furrow of mammalian cells has a distinct lipid and protein composition from the rest of the plasma membrane. This may reflect a requirement for both increased surface area during furrowing and for the co-ordinated delivery of intracellular signalling or membrane re-modelling activities to the correct spatial coordinates during cleavage. In this review, we discuss recent work within the area of membrane traffic and cytokinesis.
KW - ADP-Ribosylation Factors
KW - Animals
KW - Biological Transport
KW - Cell Membrane
KW - Cytokinesis
KW - Cytoplasmic Vesicles
KW - Cytoskeleton
KW - Humans
KW - I-kappa B Kinase
KW - rab GTP-Binding Proteins
KW - Journal Article
U2 - 10.1042/BST20051290
DO - 10.1042/BST20051290
M3 - Journal article
C2 - 16246101
VL - 33
SP - 1290
EP - 1294
JO - Biochemical Society Transactions
JF - Biochemical Society Transactions
SN - 0300-5127
IS - Pt 6
ER -