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Meta-analysis of Mendelian randomization studies incorporating all three genotypes

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Meta-analysis of Mendelian randomization studies incorporating all three genotypes. / Palmer, Tom M.; Thompson, John R.; Tobin, Martin D.
In: Statistics in Medicine, Vol. 27, No. 30, 30.12.2008, p. 6570-6582.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Palmer, TM, Thompson, JR & Tobin, MD 2008, 'Meta-analysis of Mendelian randomization studies incorporating all three genotypes', Statistics in Medicine, vol. 27, no. 30, pp. 6570-6582. https://doi.org/10.1002/sim.3423

APA

Palmer, T. M., Thompson, J. R., & Tobin, M. D. (2008). Meta-analysis of Mendelian randomization studies incorporating all three genotypes. Statistics in Medicine, 27(30), 6570-6582. https://doi.org/10.1002/sim.3423

Vancouver

Palmer TM, Thompson JR, Tobin MD. Meta-analysis of Mendelian randomization studies incorporating all three genotypes. Statistics in Medicine. 2008 Dec 30;27(30):6570-6582. doi: 10.1002/sim.3423

Author

Palmer, Tom M. ; Thompson, John R. ; Tobin, Martin D. / Meta-analysis of Mendelian randomization studies incorporating all three genotypes. In: Statistics in Medicine. 2008 ; Vol. 27, No. 30. pp. 6570-6582.

Bibtex

@article{8296a59b5e6242f199f18404243bcca7,
title = "Meta-analysis of Mendelian randomization studies incorporating all three genotypes",
abstract = "In Mendelian randomization a carefully selected gene is used as an instrumental variable in the estimation of the association between a biological phenotype and a disease. A study using Mendelian randomization will have information on an individual's disease status, the genotype and the phenotype. The phenotype must be on the causal pathway between gene and disease for the instrumental-variable analysis to be valid. For a biallelic polymorphism there are three possible genotypes with which to compare disease risk. Existing methods select two of the three possible genotypes for use in a Mendelian randomization analysis. Multivariate meta-analysis models for Mendelian randomization case-control studies are proposed, which extend previous methods by estimating the pooled phenotype-disease association across both genotype comparisons by using the gene-disease log odds ratios and differences in mean phenotypes. The methods are illustrated using a meta-analysis of the effect of a gene related to collagen production on bone mineral density and osteoporotic fracture.",
keywords = "Bone Density, Case-Control Studies, Collagen Type I, Genotype, Humans, Meta-Analysis as Topic, Models, Genetic, Models, Statistical, Osteoporosis, Phenotype, Polymorphism, Genetic, Random Allocation, Risk",
author = "Palmer, {Tom M.} and Thompson, {John R.} and Tobin, {Martin D.}",
note = " Copyright 2008 John Wiley & Sons, Ltd.",
year = "2008",
month = dec,
day = "30",
doi = "10.1002/sim.3423",
language = "English",
volume = "27",
pages = "6570--6582",
journal = "Statistics in Medicine",
issn = "0277-6715",
publisher = "John Wiley and Sons Ltd",
number = "30",

}

RIS

TY - JOUR

T1 - Meta-analysis of Mendelian randomization studies incorporating all three genotypes

AU - Palmer, Tom M.

AU - Thompson, John R.

AU - Tobin, Martin D.

N1 - Copyright 2008 John Wiley & Sons, Ltd.

PY - 2008/12/30

Y1 - 2008/12/30

N2 - In Mendelian randomization a carefully selected gene is used as an instrumental variable in the estimation of the association between a biological phenotype and a disease. A study using Mendelian randomization will have information on an individual's disease status, the genotype and the phenotype. The phenotype must be on the causal pathway between gene and disease for the instrumental-variable analysis to be valid. For a biallelic polymorphism there are three possible genotypes with which to compare disease risk. Existing methods select two of the three possible genotypes for use in a Mendelian randomization analysis. Multivariate meta-analysis models for Mendelian randomization case-control studies are proposed, which extend previous methods by estimating the pooled phenotype-disease association across both genotype comparisons by using the gene-disease log odds ratios and differences in mean phenotypes. The methods are illustrated using a meta-analysis of the effect of a gene related to collagen production on bone mineral density and osteoporotic fracture.

AB - In Mendelian randomization a carefully selected gene is used as an instrumental variable in the estimation of the association between a biological phenotype and a disease. A study using Mendelian randomization will have information on an individual's disease status, the genotype and the phenotype. The phenotype must be on the causal pathway between gene and disease for the instrumental-variable analysis to be valid. For a biallelic polymorphism there are three possible genotypes with which to compare disease risk. Existing methods select two of the three possible genotypes for use in a Mendelian randomization analysis. Multivariate meta-analysis models for Mendelian randomization case-control studies are proposed, which extend previous methods by estimating the pooled phenotype-disease association across both genotype comparisons by using the gene-disease log odds ratios and differences in mean phenotypes. The methods are illustrated using a meta-analysis of the effect of a gene related to collagen production on bone mineral density and osteoporotic fracture.

KW - Bone Density

KW - Case-Control Studies

KW - Collagen Type I

KW - Genotype

KW - Humans

KW - Meta-Analysis as Topic

KW - Models, Genetic

KW - Models, Statistical

KW - Osteoporosis

KW - Phenotype

KW - Polymorphism, Genetic

KW - Random Allocation

KW - Risk

U2 - 10.1002/sim.3423

DO - 10.1002/sim.3423

M3 - Journal article

C2 - 18767201

VL - 27

SP - 6570

EP - 6582

JO - Statistics in Medicine

JF - Statistics in Medicine

SN - 0277-6715

IS - 30

ER -