Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Metabolic and endocrine diseases, cartilage calcification and arthritis
AU - Taylor, Adam
PY - 2013/3
Y1 - 2013/3
N2 - PURPOSE OF REVIEW:Osteoarthritis is the most common form of rheumatologic disease, with numerous factors increasing the risk of developing the condition; calcification of cartilage is common place in osteoarthritis. Regardless of these risk factors, certain disorders predispose individuals to developing arthritis. Pathologic mechanisms in cartilage calcification and advances in their understanding are reviewed alongside metabolic and endocrine arthritis.RECENT FINDINGS:There is growing evidence suggesting that changes in chondrocytes and the extracellular environment both contribute to the calcification. Further evidence suggests that signaling cascades that are involved in physiological mineralisation are involved in the pathological process(es); data in mouse models continue to add weight to these hypotheses and correlate with human osteoarthritis data. Recent study of rare forms of arthritis is adding useful information that may help understand joint diseases in the general population and how therapies may be targeted.SUMMARY:There is little doubt that calcium-containing crystals are involved in the osteoarthritis process contributing both biomechanically and biochemically. Understanding the processes involved provides important therapeutic opportunities. Furthermore, important information is often discovered in studying rare conditions in which these pathologies are inevitable
AB - PURPOSE OF REVIEW:Osteoarthritis is the most common form of rheumatologic disease, with numerous factors increasing the risk of developing the condition; calcification of cartilage is common place in osteoarthritis. Regardless of these risk factors, certain disorders predispose individuals to developing arthritis. Pathologic mechanisms in cartilage calcification and advances in their understanding are reviewed alongside metabolic and endocrine arthritis.RECENT FINDINGS:There is growing evidence suggesting that changes in chondrocytes and the extracellular environment both contribute to the calcification. Further evidence suggests that signaling cascades that are involved in physiological mineralisation are involved in the pathological process(es); data in mouse models continue to add weight to these hypotheses and correlate with human osteoarthritis data. Recent study of rare forms of arthritis is adding useful information that may help understand joint diseases in the general population and how therapies may be targeted.SUMMARY:There is little doubt that calcium-containing crystals are involved in the osteoarthritis process contributing both biomechanically and biochemically. Understanding the processes involved provides important therapeutic opportunities. Furthermore, important information is often discovered in studying rare conditions in which these pathologies are inevitable
KW - alkaptonuria
KW - arthritis
KW - cartilage calcification
KW - crystal
U2 - 10.1097/BOR.0b013e32835d8ff8
DO - 10.1097/BOR.0b013e32835d8ff8
M3 - Journal article
VL - 25
SP - 198
EP - 203
JO - Current Opinion in Rheumatology
JF - Current Opinion in Rheumatology
SN - 1531-6963
IS - 2
ER -