Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Microstructure and corrosion resistance of powder metallurgical Ti-Nb-Zr-Mg alloys with low modulus for biomedical application
AU - Li, G.
AU - Shen, E.
AU - Liang, L.
AU - Li, K.
AU - Lu, Y.
AU - Zhu, W.
AU - Tian, Y.
AU - Baker, I.
AU - Wu, H.
PY - 2022/10/31
Y1 - 2022/10/31
N2 - Due to their bioinert nature, titanium alloys show poor bone-implant integration and insufficient osseointegration in vivo. In this study, a series of low elastic modulus bioactive titanium alloys with a nominal composition of Ti-13Nb-13Zr-1.25 Mg (wt%) were prepared using mechanical alloying and spark plasma sintering techniques. The microstructures, mechanical properties, degradation behaviors and in vitro bioactivities of these alloys were systematically investigated. After sintering at 700 °C, the α-Ti, β-Ti and Nb (Zr)-rich phases were present, and the Mg was uniformly distributed. In addition to above-mentioned phases, the α″ phase was found after sintering at 800 °C or 900 °C. The density, elastic modulus, yield strength, ultimate compressive strength and corrosion resistance all increased with increasing sintering temperature. After sintering at 900 °C, the alloy exhibited high density (99.8%), good compressive strength (1417.2 MPa) and excellent corrosion resistance. In addition, it had a lower elastic modulus (~69 GPa) than that of the biomedical alloy Ti–13Nb–13Zr (~80 GPa). In vitro experiments showed that the alloys sintered at either 800 °C or 900 °C promoted cell adhesion and proliferation. However, the alloy sintered at 700 °C inhibited cell proliferation, which was due to the greater release of Mg 2+. Thus, the optimally-processed Ti-Nb-Zr-Mg alloy sintered at 900 °C shows immense potential as a biomedical material.
AB - Due to their bioinert nature, titanium alloys show poor bone-implant integration and insufficient osseointegration in vivo. In this study, a series of low elastic modulus bioactive titanium alloys with a nominal composition of Ti-13Nb-13Zr-1.25 Mg (wt%) were prepared using mechanical alloying and spark plasma sintering techniques. The microstructures, mechanical properties, degradation behaviors and in vitro bioactivities of these alloys were systematically investigated. After sintering at 700 °C, the α-Ti, β-Ti and Nb (Zr)-rich phases were present, and the Mg was uniformly distributed. In addition to above-mentioned phases, the α″ phase was found after sintering at 800 °C or 900 °C. The density, elastic modulus, yield strength, ultimate compressive strength and corrosion resistance all increased with increasing sintering temperature. After sintering at 900 °C, the alloy exhibited high density (99.8%), good compressive strength (1417.2 MPa) and excellent corrosion resistance. In addition, it had a lower elastic modulus (~69 GPa) than that of the biomedical alloy Ti–13Nb–13Zr (~80 GPa). In vitro experiments showed that the alloys sintered at either 800 °C or 900 °C promoted cell adhesion and proliferation. However, the alloy sintered at 700 °C inhibited cell proliferation, which was due to the greater release of Mg 2+. Thus, the optimally-processed Ti-Nb-Zr-Mg alloy sintered at 900 °C shows immense potential as a biomedical material.
KW - Bioactivity
KW - Corrosion resistance
KW - Low elastic modulus
KW - Powder metallurgy
KW - Ti-Nb-Zr-mg alloy
KW - Alloying elements
KW - Biocompatibility
KW - Biomechanics
KW - Bone
KW - Cell adhesion
KW - Cell proliferation
KW - Compressive strength
KW - Corrosion resistant alloys
KW - Elastic moduli
KW - Magnesium alloys
KW - Medical applications
KW - Metal implants
KW - Microstructure
KW - Niobium alloys
KW - Spark plasma sintering
KW - Titanium alloys
KW - Bioinert
KW - Biomedical applications
KW - Bone implant
KW - Low-modulus
KW - Mg alloy
KW - Osseointegration
KW - Powder metallurgical
KW - Ti-nb-zr-mg alloy
KW - Titanium (alloys)
U2 - 10.1016/j.matchar.2022.112223
DO - 10.1016/j.matchar.2022.112223
M3 - Journal article
VL - 192
JO - Materials Characterization
JF - Materials Characterization
SN - 1044-5803
M1 - 112223
ER -