Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Modelling the helium plasma jet delivery of reactive species into a 3D cancer tumour
AU - Szili, Endre J.
AU - Oh, Jun Seok
AU - Fukuhara, Hideo
AU - Bhatia, Rishabh
AU - Gaur, Nishtha
AU - Nguyen, Cuong K.
AU - Hong, Sung Ha
AU - Ito, Satsuki
AU - Ogawa, Kotaro
AU - Kawada, Chiaki
AU - Shuin, Taro
AU - Tsuda, Masayuki
AU - Furihata, Mutsuo
AU - Kurabayashi, Atsushi
AU - Furuta, Hiroshi
AU - Ito, Masafumi
AU - Inoue, Keiji
AU - Hatta, Akimitsu
AU - Short, Robert D.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Cold atmospheric plasmas have attracted significant worldwide attention for their potential beneficial effects in cancer therapy. In order to further improve the effectiveness of plasma in cancer therapy, it is important to understand the generation and transport of plasma reactive species into tissue fluids, tissues and cells, and moreover the rates and depths of delivery, particularly across physical barriers such as skin. In this study, helium (He) plasma jet treatment of a 3D cancer tumour, grown on the back of a live mouse, induced apoptosis within the tumour to a depth of 2.8 mm. The He plasma jet was shown to deliver reactive oxygen species through the unbroken skin barrier before penetrating through the entire depth of the tumour. The depth and rate of transport of He plasma jet generated H2O2, NO3 - and NO2 -, as well as aqueous oxygen [O2(aq)], was then tracked in an agarose tissue model. This provided an approximation of the H2O2, NO3 -, NO2 - and O2(aq) concentrations that might have been generated during the He plasma jet treatment of the 3D tumour. It is proposed that the He plasma jet can induce apoptosis within a tumour by the 'deep' delivery of H2O2, NO3 - and NO2 - coupled with O2(aq); the latter raising oxygen tension in hypoxic tissue.
AB - Cold atmospheric plasmas have attracted significant worldwide attention for their potential beneficial effects in cancer therapy. In order to further improve the effectiveness of plasma in cancer therapy, it is important to understand the generation and transport of plasma reactive species into tissue fluids, tissues and cells, and moreover the rates and depths of delivery, particularly across physical barriers such as skin. In this study, helium (He) plasma jet treatment of a 3D cancer tumour, grown on the back of a live mouse, induced apoptosis within the tumour to a depth of 2.8 mm. The He plasma jet was shown to deliver reactive oxygen species through the unbroken skin barrier before penetrating through the entire depth of the tumour. The depth and rate of transport of He plasma jet generated H2O2, NO3 - and NO2 -, as well as aqueous oxygen [O2(aq)], was then tracked in an agarose tissue model. This provided an approximation of the H2O2, NO3 -, NO2 - and O2(aq) concentrations that might have been generated during the He plasma jet treatment of the 3D tumour. It is proposed that the He plasma jet can induce apoptosis within a tumour by the 'deep' delivery of H2O2, NO3 - and NO2 - coupled with O2(aq); the latter raising oxygen tension in hypoxic tissue.
KW - cancer therapy
KW - hyperbaric medicine
KW - hypoxia
KW - plasma jet
KW - reactive oxygen species (ROS) and reactive nitrogen species (RNS)
KW - tissue model
KW - tissue oxygenation
U2 - 10.1088/1361-6595/aa9b3b
DO - 10.1088/1361-6595/aa9b3b
M3 - Journal article
AN - SCOPUS:85041416883
VL - 27
JO - Plasma Sources Science and Technology
JF - Plasma Sources Science and Technology
SN - 0963-0252
IS - 1
M1 - 014001
ER -