Home > Research > Publications & Outputs > Multifaceted transforming growth factor-beta (T...

Text available via DOI:

View graph of relations

Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma

Research output: Contribution to Journal/MagazineReview articlepeer-review

Published
  • Joanna L. Birch
  • Barry J. Coull
  • Lindsay C. Spender
  • Courtney Watt
  • Alice Willison
  • Nelofer Syed
  • Anthony J. Chalmers
  • M. Kismet Hossain-Ibrahim
  • Gareth J. Inman
Close
Article number109638
<mark>Journal publication date</mark>08/2020
<mark>Journal</mark>Cellular Signalling
Volume72
Pages (from-to)109638
Publication StatusPublished
<mark>Original language</mark>English

Abstract

Glioblastoma (GBM) is an aggressive and devastating primary brain cancer which responds very poorly to treatment. The average survival time of patients is only 14–15 months from diagnosis so there is a clear and unmet need for the development of novel targeted therapies to improve patient outcomes. The multifunctional cytokine TGFβ plays fundamental roles in development, adult tissue homeostasis, tissue wound repair and immune responses. Dysfunction of TGFβ signalling has been implicated in both the development and progression of many tumour types including GBM, thereby potentially providing an actionable target for its treatment. This review will examine TGFβ signalling mechanisms and their role in the development and progression of GBM. The targeting of TGFβ signalling using a variety of approaches including the TGFβ binding protein Decorin will be highlighted as attractive therapeutic strategies.

Bibliographic note

Funding Information: The authors acknowledge grants from Cancer Research UK (A29802) and Tenovus Tayside , UK. Publisher Copyright: © 2020 Elsevier Inc.