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Mutation Induction by Ionizing Radiation in Three Human Bladder Tumour Cell Lines.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • C. R. H. Kent
  • S. Edwards
  • T. J. McMillan
<mark>Journal publication date</mark>01/1993
<mark>Journal</mark>International Journal of Radiation Biology
Issue number1
Number of pages5
Pages (from-to)1-5
Publication StatusPublished
<mark>Original language</mark>English


Mutation induction at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus has been studied in three human bladder tumour cell lines of varying radiosensitivity. U1-S40b, a radiosensitive mutant clone of MGH-U1, has been previously reported to show no difference in split-dose recovery or low dose-rate sparing, but to have an impaired repair fidelity when compared to its parent line. In this paper we have shown that U1-S40b is less mutable at the hprt locus at a similar level of survival. This may represent an increased incidence of severe or non-repairable lesions, making hprt- mutants poorly recoverable in U1-S40b when compared to MGH-U1. No difference was seen in mutation induction between MGH-U1 and RT112, another human bladder tumour cell line of similar radiosensitivity to MGH-U1.