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Mutation Induction by Ionizing Radiation in Three Human Bladder Tumour Cell Lines.

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Mutation Induction by Ionizing Radiation in Three Human Bladder Tumour Cell Lines. / Kent, C. R. H.; Edwards, S.; McMillan, T. J.
In: International Journal of Radiation Biology, Vol. 63, No. 1, 01.1993, p. 1-5.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Kent, CRH, Edwards, S & McMillan, TJ 1993, 'Mutation Induction by Ionizing Radiation in Three Human Bladder Tumour Cell Lines.', International Journal of Radiation Biology, vol. 63, no. 1, pp. 1-5. https://doi.org/10.1080/09553009314550011

APA

Kent, C. R. H., Edwards, S., & McMillan, T. J. (1993). Mutation Induction by Ionizing Radiation in Three Human Bladder Tumour Cell Lines. International Journal of Radiation Biology, 63(1), 1-5. https://doi.org/10.1080/09553009314550011

Vancouver

Kent CRH, Edwards S, McMillan TJ. Mutation Induction by Ionizing Radiation in Three Human Bladder Tumour Cell Lines. International Journal of Radiation Biology. 1993 Jan;63(1):1-5. doi: 10.1080/09553009314550011

Author

Kent, C. R. H. ; Edwards, S. ; McMillan, T. J. / Mutation Induction by Ionizing Radiation in Three Human Bladder Tumour Cell Lines. In: International Journal of Radiation Biology. 1993 ; Vol. 63, No. 1. pp. 1-5.

Bibtex

@article{209f1feed2e94b388b794c61a8bbc719,
title = "Mutation Induction by Ionizing Radiation in Three Human Bladder Tumour Cell Lines.",
abstract = "Mutation induction at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus has been studied in three human bladder tumour cell lines of varying radiosensitivity. U1-S40b, a radiosensitive mutant clone of MGH-U1, has been previously reported to show no difference in split-dose recovery or low dose-rate sparing, but to have an impaired repair fidelity when compared to its parent line. In this paper we have shown that U1-S40b is less mutable at the hprt locus at a similar level of survival. This may represent an increased incidence of severe or non-repairable lesions, making hprt- mutants poorly recoverable in U1-S40b when compared to MGH-U1. No difference was seen in mutation induction between MGH-U1 and RT112, another human bladder tumour cell line of similar radiosensitivity to MGH-U1.",
author = "Kent, {C. R. H.} and S. Edwards and McMillan, {T. J.}",
year = "1993",
month = jan,
doi = "10.1080/09553009314550011",
language = "English",
volume = "63",
pages = "1--5",
journal = "International Journal of Radiation Biology",
issn = "0955-3002",
publisher = "Informa Healthcare",
number = "1",

}

RIS

TY - JOUR

T1 - Mutation Induction by Ionizing Radiation in Three Human Bladder Tumour Cell Lines.

AU - Kent, C. R. H.

AU - Edwards, S.

AU - McMillan, T. J.

PY - 1993/1

Y1 - 1993/1

N2 - Mutation induction at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus has been studied in three human bladder tumour cell lines of varying radiosensitivity. U1-S40b, a radiosensitive mutant clone of MGH-U1, has been previously reported to show no difference in split-dose recovery or low dose-rate sparing, but to have an impaired repair fidelity when compared to its parent line. In this paper we have shown that U1-S40b is less mutable at the hprt locus at a similar level of survival. This may represent an increased incidence of severe or non-repairable lesions, making hprt- mutants poorly recoverable in U1-S40b when compared to MGH-U1. No difference was seen in mutation induction between MGH-U1 and RT112, another human bladder tumour cell line of similar radiosensitivity to MGH-U1.

AB - Mutation induction at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus has been studied in three human bladder tumour cell lines of varying radiosensitivity. U1-S40b, a radiosensitive mutant clone of MGH-U1, has been previously reported to show no difference in split-dose recovery or low dose-rate sparing, but to have an impaired repair fidelity when compared to its parent line. In this paper we have shown that U1-S40b is less mutable at the hprt locus at a similar level of survival. This may represent an increased incidence of severe or non-repairable lesions, making hprt- mutants poorly recoverable in U1-S40b when compared to MGH-U1. No difference was seen in mutation induction between MGH-U1 and RT112, another human bladder tumour cell line of similar radiosensitivity to MGH-U1.

U2 - 10.1080/09553009314550011

DO - 10.1080/09553009314550011

M3 - Journal article

VL - 63

SP - 1

EP - 5

JO - International Journal of Radiation Biology

JF - International Journal of Radiation Biology

SN - 0955-3002

IS - 1

ER -