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  • revised cs-2020-04360x

    Rights statement: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acscatal.0c04360

    Accepted author manuscript, 1.02 MB, PDF document

    Embargo ends: 18/12/21

    Available under license: CC BY-NC: Creative Commons Attribution-NonCommercial 4.0 International License

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NADH regeneration: a case study of Pt-catalyzed NAD+ reduction with H2

Research output: Contribution to journalLetterpeer-review

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  • Tony Saba
  • Jianwei Li
  • Joseph W.H. Burnett
  • Russell F. Howe
  • Panagiotis N. Kechagiopoulos
  • Xiaodong Wang
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<mark>Journal publication date</mark>1/01/2021
<mark>Journal</mark>ACS Catalysis
Issue number1
Volume11
Number of pages7
Pages (from-to)283–289
Publication StatusPublished
Early online date18/12/20
<mark>Original language</mark>English

Abstract

This study shows the importance of resolving catalytic performance in the regeneration of the reduced form of nicotinamide adenine dinucleotide (NADH) through activity measurements based on NAD+ conversion and the closure of mass balance via by-product quantification. This approach is applied to assess the performance of supported platinum catalysts with varying points of zero charge, utilizing H2 as a reductant. It was found that Pt/SiO2, which exhibits a net negative charge under the reaction conditions, outperforms the neutral Pt/C and positively charged Pt/MgO due to the favorable electrostatic attraction between the catalyst surface and positively charged (+1) nicotinamide ring. NMR spectroscopy identifies side-products formed during NAD+ hydrogenation.

Bibliographic note

This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acscatal.0c04360