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    Rights statement: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acscatal.0c04360

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NADH regeneration: a case study of Pt-catalyzed NAD+ reduction with H2

Research output: Contribution to Journal/Magazine › Letter › peer-review

Published

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NADH regeneration: a case study of Pt-catalyzed NAD+ reduction with H2. / Saba, Tony; Li, Jianwei; Burnett, Joseph W.H. et al.
In: ACS Catalysis, Vol. 11, No. 1, 01.01.2021, p. 283–289.

Research output: Contribution to Journal/Magazine › Letter › peer-review

Harvard

Saba, T, Li, J, Burnett, JWH, Howe, RF, Kechagiopoulos, PN & Wang, X 2021, 'NADH regeneration: a case study of Pt-catalyzed NAD+ reduction with H2', ACS Catalysis, vol. 11, no. 1, pp. 283–289. https://doi.org/10.1021/acscatal.0c04360

APA

Saba, T., Li, J., Burnett, J. W. H., Howe, R. F., Kechagiopoulos, P. N., & Wang, X. (2021). NADH regeneration: a case study of Pt-catalyzed NAD+ reduction with H2. ACS Catalysis, 11(1), 283–289. https://doi.org/10.1021/acscatal.0c04360

Vancouver

Saba T, Li J, Burnett JWH, Howe RF, Kechagiopoulos PN, Wang X. NADH regeneration: a case study of Pt-catalyzed NAD+ reduction with H2. ACS Catalysis. 2021 Jan 1;11(1):283–289. Epub 2020 Dec 18. doi: 10.1021/acscatal.0c04360

Author

Saba, Tony ; Li, Jianwei ; Burnett, Joseph W.H. et al. / NADH regeneration : a case study of Pt-catalyzed NAD+ reduction with H2. In: ACS Catalysis. 2021 ; Vol. 11, No. 1. pp. 283–289.

Bibtex

@article{6412aa85e42d429b86f3f8ac94f7d905,
title = "NADH regeneration: a case study of Pt-catalyzed NAD+ reduction with H2",
abstract = "This study shows the importance of resolving catalytic performance in the regeneration of the reduced form of nicotinamide adenine dinucleotide (NADH) through activity measurements based on NAD+ conversion and the closure of mass balance via by-product quantification. This approach is applied to assess the performance of supported platinum catalysts with varying points of zero charge, utilizing H2 as a reductant. It was found that Pt/SiO2, which exhibits a net negative charge under the reaction conditions, outperforms the neutral Pt/C and positively charged Pt/MgO due to the favorable electrostatic attraction between the catalyst surface and positively charged (+1) nicotinamide ring. NMR spectroscopy identifies side-products formed during NAD+ hydrogenation.",
author = "Tony Saba and Jianwei Li and Burnett, {Joseph W.H.} and Howe, {Russell F.} and Kechagiopoulos, {Panagiotis N.} and Xiaodong Wang",
note = "This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright {\textcopyright} American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acscatal.0c04360",
year = "2021",
month = jan,
day = "1",
doi = "10.1021/acscatal.0c04360",
language = "English",
volume = "11",
pages = "283–289",
journal = "ACS Catalysis",
issn = "2155-5435",
publisher = "American Chemical Society",
number = "1",

}

RIS

TY - JOUR

T1 - NADH regeneration

T2 - a case study of Pt-catalyzed NAD+ reduction with H2

AU - Saba, Tony

AU - Li, Jianwei

AU - Burnett, Joseph W.H.

AU - Howe, Russell F.

AU - Kechagiopoulos, Panagiotis N.

AU - Wang, Xiaodong

N1 - This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acscatal.0c04360

PY - 2021/1/1

Y1 - 2021/1/1

N2 - This study shows the importance of resolving catalytic performance in the regeneration of the reduced form of nicotinamide adenine dinucleotide (NADH) through activity measurements based on NAD+ conversion and the closure of mass balance via by-product quantification. This approach is applied to assess the performance of supported platinum catalysts with varying points of zero charge, utilizing H2 as a reductant. It was found that Pt/SiO2, which exhibits a net negative charge under the reaction conditions, outperforms the neutral Pt/C and positively charged Pt/MgO due to the favorable electrostatic attraction between the catalyst surface and positively charged (+1) nicotinamide ring. NMR spectroscopy identifies side-products formed during NAD+ hydrogenation.

AB - This study shows the importance of resolving catalytic performance in the regeneration of the reduced form of nicotinamide adenine dinucleotide (NADH) through activity measurements based on NAD+ conversion and the closure of mass balance via by-product quantification. This approach is applied to assess the performance of supported platinum catalysts with varying points of zero charge, utilizing H2 as a reductant. It was found that Pt/SiO2, which exhibits a net negative charge under the reaction conditions, outperforms the neutral Pt/C and positively charged Pt/MgO due to the favorable electrostatic attraction between the catalyst surface and positively charged (+1) nicotinamide ring. NMR spectroscopy identifies side-products formed during NAD+ hydrogenation.

U2 - 10.1021/acscatal.0c04360

DO - 10.1021/acscatal.0c04360

M3 - Letter

VL - 11

SP - 283

EP - 289

JO - ACS Catalysis

JF - ACS Catalysis

SN - 2155-5435

IS - 1

ER -