Atomic Foce Micoscopy is an especially useful tool in studying biological systems, because not only can they image and manipulate samples at molecular resolution, they can do so in physiological conditions – in liquid, and in air if desired as well as provide direct nanomechanical characterisation, which are essential for understanding the formation principles of these systems and the molecular mechanisms that govern their unique functionality. Nacre (mother-of-pearl), Amyloid fibres and lipid bilayer liposomes were the subject of Ultrasonic Force Microscopy (UFM) investigation.