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NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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  • Pavla Krotka
  • Katharina Hees
  • Peter Jacko
  • Dominic Magirr
  • Martin Posch
  • Marta Bofill Roig
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Article number101437
<mark>Journal publication date</mark>31/07/2023
<mark>Journal</mark>SoftwareX
Volume23
Publication StatusPublished
Early online date22/06/23
<mark>Original language</mark>English

Abstract

Platform trials evaluate the efficacy of multiple treatments, allowing for late entry of the experimental arms and enabling efficiency gains by sharing controls. The power of individual treatment-control comparisons in such trials can be improved by utilizing non-concurrent controls (NCC) in the analysis. We present the R-package NCC for the design and analysis of platform trials using non-concurrent controls. NCC allows for simulating platform trials and evaluating the properties of analysis methods that make use of non-concurrent controls in a variety of settings. We describe the main NCC functions and show how to use the package to simulate and analyse platform trials by means of specific examples.