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NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls. / Krotka, Pavla; Hees, Katharina; Jacko, Peter et al.
In: SoftwareX, Vol. 23, 101437, 31.07.2023.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Krotka, P, Hees, K, Jacko, P, Magirr, D, Posch, M & Bofill Roig, M 2023, 'NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls', SoftwareX, vol. 23, 101437. https://doi.org/10.1016/j.softx.2023.101437

APA

Krotka, P., Hees, K., Jacko, P., Magirr, D., Posch, M., & Bofill Roig, M. (2023). NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls. SoftwareX, 23, Article 101437. https://doi.org/10.1016/j.softx.2023.101437

Vancouver

Krotka P, Hees K, Jacko P, Magirr D, Posch M, Bofill Roig M. NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls. SoftwareX. 2023 Jul 31;23:101437. Epub 2023 Jun 22. doi: 10.1016/j.softx.2023.101437

Author

Krotka, Pavla ; Hees, Katharina ; Jacko, Peter et al. / NCC : An R-package for analysis and simulation of platform trials with non-concurrent controls. In: SoftwareX. 2023 ; Vol. 23.

Bibtex

@article{ab7878c2f1be47148171ef5ba06a4882,
title = "NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls",
abstract = "Platform trials evaluate the efficacy of multiple treatments, allowing for late entry of the experimental arms and enabling efficiency gains by sharing controls. The power of individual treatment-control comparisons in such trials can be improved by utilizing non-concurrent controls (NCC) in the analysis. We present the R-package NCC for the design and analysis of platform trials using non-concurrent controls. NCC allows for simulating platform trials and evaluating the properties of analysis methods that make use of non-concurrent controls in a variety of settings. We describe the main NCC functions and show how to use the package to simulate and analyse platform trials by means of specific examples.",
keywords = "Clinical trial simulation, Non-concurrent controls, Platform trials, Shared controls, Statistics",
author = "Pavla Krotka and Katharina Hees and Peter Jacko and Dominic Magirr and Martin Posch and {Bofill Roig}, Marta",
year = "2023",
month = jul,
day = "31",
doi = "10.1016/j.softx.2023.101437",
language = "English",
volume = "23",
journal = "SoftwareX",
issn = "2352-7110",
publisher = "Elsevier Science B.V.",

}

RIS

TY - JOUR

T1 - NCC

T2 - An R-package for analysis and simulation of platform trials with non-concurrent controls

AU - Krotka, Pavla

AU - Hees, Katharina

AU - Jacko, Peter

AU - Magirr, Dominic

AU - Posch, Martin

AU - Bofill Roig, Marta

PY - 2023/7/31

Y1 - 2023/7/31

N2 - Platform trials evaluate the efficacy of multiple treatments, allowing for late entry of the experimental arms and enabling efficiency gains by sharing controls. The power of individual treatment-control comparisons in such trials can be improved by utilizing non-concurrent controls (NCC) in the analysis. We present the R-package NCC for the design and analysis of platform trials using non-concurrent controls. NCC allows for simulating platform trials and evaluating the properties of analysis methods that make use of non-concurrent controls in a variety of settings. We describe the main NCC functions and show how to use the package to simulate and analyse platform trials by means of specific examples.

AB - Platform trials evaluate the efficacy of multiple treatments, allowing for late entry of the experimental arms and enabling efficiency gains by sharing controls. The power of individual treatment-control comparisons in such trials can be improved by utilizing non-concurrent controls (NCC) in the analysis. We present the R-package NCC for the design and analysis of platform trials using non-concurrent controls. NCC allows for simulating platform trials and evaluating the properties of analysis methods that make use of non-concurrent controls in a variety of settings. We describe the main NCC functions and show how to use the package to simulate and analyse platform trials by means of specific examples.

KW - Clinical trial simulation

KW - Non-concurrent controls

KW - Platform trials

KW - Shared controls

KW - Statistics

U2 - 10.1016/j.softx.2023.101437

DO - 10.1016/j.softx.2023.101437

M3 - Journal article

AN - SCOPUS:85170650508

VL - 23

JO - SoftwareX

JF - SoftwareX

SN - 2352-7110

M1 - 101437

ER -