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N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder. / Moreno-Villanueva, M.; Morath, J.; Vanhooren, V. et al.
In: Translational Psychiatry, Vol. 3, e320, 2013.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Moreno-Villanueva, M, Morath, J, Vanhooren, V, Elbert, T, Kolassa, S, Libert, C, Bürkle, A & Kolassa, I-T 2013, 'N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder', Translational Psychiatry, vol. 3, e320. https://doi.org/10.1038/tp.2013.93

APA

Moreno-Villanueva, M., Morath, J., Vanhooren, V., Elbert, T., Kolassa, S., Libert, C., Bürkle, A., & Kolassa, I-T. (2013). N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder. Translational Psychiatry, 3, Article e320. https://doi.org/10.1038/tp.2013.93

Vancouver

Moreno-Villanueva M, Morath J, Vanhooren V, Elbert T, Kolassa S, Libert C et al. N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder. Translational Psychiatry. 2013;3:e320. doi: 10.1038/tp.2013.93

Author

Moreno-Villanueva, M. ; Morath, J. ; Vanhooren, V. et al. / N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder. In: Translational Psychiatry. 2013 ; Vol. 3.

Bibtex

@article{3fba65039d744adbae16c48c608a9d1e,
title = "N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder",
abstract = "The prevalence of age-related diseases is increased in individuals with post-traumatic stress disorder (PTSD). However, the underlying biological mechanisms are still unclear. N-glycosylation is an age-dependent process, identified as a biomarker for physiological aging (GlycoAge Test). To investigate whether traumatic stress accelerates the aging process, we analyzed the N-glycosylation profile in n=13 individuals with PTSD, n=9 trauma-exposed individuals and in n=10 low-stress control subjects. Individuals with PTSD and trauma-exposed individuals presented an upward shift in the GlycoAge Test, equivalent to an advancement of the aging process by 15 additional years. Trauma-exposed individuals presented an intermediate N-glycosylation profile positioned between severely traumatized individuals with PTSD and low-stress control subjects. In conclusion, our data suggest that cumulative exposure to traumatic stressors accelerates the process of physiological aging.",
author = "M. Moreno-Villanueva and J. Morath and V. Vanhooren and T. Elbert and S. Kolassa and C. Libert and A. B{\"u}rkle and I.-T. Kolassa",
year = "2013",
doi = "10.1038/tp.2013.93",
language = "English",
volume = "3",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder

AU - Moreno-Villanueva, M.

AU - Morath, J.

AU - Vanhooren, V.

AU - Elbert, T.

AU - Kolassa, S.

AU - Libert, C.

AU - Bürkle, A.

AU - Kolassa, I.-T.

PY - 2013

Y1 - 2013

N2 - The prevalence of age-related diseases is increased in individuals with post-traumatic stress disorder (PTSD). However, the underlying biological mechanisms are still unclear. N-glycosylation is an age-dependent process, identified as a biomarker for physiological aging (GlycoAge Test). To investigate whether traumatic stress accelerates the aging process, we analyzed the N-glycosylation profile in n=13 individuals with PTSD, n=9 trauma-exposed individuals and in n=10 low-stress control subjects. Individuals with PTSD and trauma-exposed individuals presented an upward shift in the GlycoAge Test, equivalent to an advancement of the aging process by 15 additional years. Trauma-exposed individuals presented an intermediate N-glycosylation profile positioned between severely traumatized individuals with PTSD and low-stress control subjects. In conclusion, our data suggest that cumulative exposure to traumatic stressors accelerates the process of physiological aging.

AB - The prevalence of age-related diseases is increased in individuals with post-traumatic stress disorder (PTSD). However, the underlying biological mechanisms are still unclear. N-glycosylation is an age-dependent process, identified as a biomarker for physiological aging (GlycoAge Test). To investigate whether traumatic stress accelerates the aging process, we analyzed the N-glycosylation profile in n=13 individuals with PTSD, n=9 trauma-exposed individuals and in n=10 low-stress control subjects. Individuals with PTSD and trauma-exposed individuals presented an upward shift in the GlycoAge Test, equivalent to an advancement of the aging process by 15 additional years. Trauma-exposed individuals presented an intermediate N-glycosylation profile positioned between severely traumatized individuals with PTSD and low-stress control subjects. In conclusion, our data suggest that cumulative exposure to traumatic stressors accelerates the process of physiological aging.

U2 - 10.1038/tp.2013.93

DO - 10.1038/tp.2013.93

M3 - Journal article

VL - 3

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

M1 - e320

ER -