Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Non-contact micro-cantilevers detect photothermally induced vibrations that can segregate different categories of exfoliative cervical cytology.
AU - Hammiche, Azzedine
AU - Walsh, Michael J.
AU - Pollock, Hubert M.
AU - Martin-Hirsch, Pierre L.
AU - Martin, Francis L.
PY - 2007/6/10
Y1 - 2007/6/10
N2 - We implemented a non-contact photo-thermo-mechanical recording method whereby a silicon nitride atomic force microscopy cantilever is placed several micrometer above the surface of samples. Samples were illuminated with infrared (IR) radiation after which, cantilever mechanical vibrations were optically sensed. Following spectrometric acquisition and Fourier transformation, true IR absorption spectra were obtained. With multivariate analysis, segregation between different categories of exfoliative cervical cytology was obtained. This approach points towards the implementation of a novel near-field system that allows IR spectral analysis without probe contamination.
AB - We implemented a non-contact photo-thermo-mechanical recording method whereby a silicon nitride atomic force microscopy cantilever is placed several micrometer above the surface of samples. Samples were illuminated with infrared (IR) radiation after which, cantilever mechanical vibrations were optically sensed. Following spectrometric acquisition and Fourier transformation, true IR absorption spectra were obtained. With multivariate analysis, segregation between different categories of exfoliative cervical cytology was obtained. This approach points towards the implementation of a novel near-field system that allows IR spectral analysis without probe contamination.
KW - Atomic force microscopy cantilever
KW - Cantilever mechanical vibrations
KW - IR spectral analysis
KW - Near-field
KW - Non-contact
KW - Photo-thermo-mechanical
U2 - 10.1016/j.jbbm.2007.01.011
DO - 10.1016/j.jbbm.2007.01.011
M3 - Journal article
VL - 70
SP - 675
EP - 677
JO - Journal of Biochemical and Biophysical Methods
JF - Journal of Biochemical and Biophysical Methods
SN - 0165-022X
IS - 4
ER -