Final published version
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Optimizing Nanohydroxyapatite Nanocomposites for Bone Tissue Engineering
AU - Lowe, B.
AU - Hardy, J.G.
AU - Walsh, L.J.
PY - 2020/1/14
Y1 - 2020/1/14
N2 - Bone tissue engineering involves the combined use of materials with functional properties to regenerate bone. Nanohydroxyapatite (nHA) can influence the behavior of cells. The functional and structural properties of nHA can be controlled during nanoparticle synthesis. This review defines the relationship between the attributes of nHA nanoparticles and their biological effects, focusing on biocompatibility, surface-area-to-volume ratio, bonding chemistry, and substrate functionality. The paper explores how these aspects have been applied in the development of scaffolds for the repair of damaged bone or regeneration of missing bone.
AB - Bone tissue engineering involves the combined use of materials with functional properties to regenerate bone. Nanohydroxyapatite (nHA) can influence the behavior of cells. The functional and structural properties of nHA can be controlled during nanoparticle synthesis. This review defines the relationship between the attributes of nHA nanoparticles and their biological effects, focusing on biocompatibility, surface-area-to-volume ratio, bonding chemistry, and substrate functionality. The paper explores how these aspects have been applied in the development of scaffolds for the repair of damaged bone or regeneration of missing bone.
U2 - 10.1021/acsomega.9b02917
DO - 10.1021/acsomega.9b02917
M3 - Journal article
C2 - 31956745
VL - 5
SP - 1
EP - 9
JO - ACS Omega
JF - ACS Omega
SN - 2470-1343
IS - 1
ER -