In this perspective, we report an opinion on overtone spectroscopy for sensing and discuss the nature of the opportunities perceived for specialists. New spectroscopic strategies can potentially be extended to detect other common toxic byproducts in a chip-scale label-free manner and to enhance the functionality of chemical and biological monitoring. Nevertheless, the full potential of overtone spectroscopy is not yet exhausted, challenges must be overcome, and new avenues await. Within this Perspective, we look at where the field currently stands, highlight several successful examples of overtone spectroscopy based sensors and detectors, and ask what it will take to advance current state-of-the-art technology. It is our intention to point out some potential blind spots and to inspire further developments.