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Oxadiazole isomers: All bioisosteres are not created equal

Research output: Contribution to journalJournal articlepeer-review

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  • Kristin Goldberg
  • Sam Groombridge
  • Julian Hudson
  • Andrew G. Leach
  • Philip A. MacFaul
  • Adrian Pickup
  • Ruth Poultney
  • James S. Scott
  • Per H. Svensson
  • Joseph Sweeney
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<mark>Journal publication date</mark>1/05/2012
<mark>Journal</mark>MedChemComm
Issue number5
Volume3
Number of pages5
Pages (from-to)600-604
Publication StatusPublished
<mark>Original language</mark>English

Abstract

Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.