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Oxadiazole isomers: All bioisosteres are not created equal

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Oxadiazole isomers: All bioisosteres are not created equal. / Goldberg, Kristin; Groombridge, Sam; Hudson, Julian et al.
In: MedChemComm, Vol. 3, No. 5, 01.05.2012, p. 600-604.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Goldberg, K, Groombridge, S, Hudson, J, Leach, AG, MacFaul, PA, Pickup, A, Poultney, R, Scott, JS, Svensson, PH & Sweeney, J 2012, 'Oxadiazole isomers: All bioisosteres are not created equal', MedChemComm, vol. 3, no. 5, pp. 600-604. https://doi.org/10.1039/c2md20054f

APA

Goldberg, K., Groombridge, S., Hudson, J., Leach, A. G., MacFaul, P. A., Pickup, A., Poultney, R., Scott, J. S., Svensson, P. H., & Sweeney, J. (2012). Oxadiazole isomers: All bioisosteres are not created equal. MedChemComm, 3(5), 600-604. https://doi.org/10.1039/c2md20054f

Vancouver

Goldberg K, Groombridge S, Hudson J, Leach AG, MacFaul PA, Pickup A et al. Oxadiazole isomers: All bioisosteres are not created equal. MedChemComm. 2012 May 1;3(5):600-604. doi: 10.1039/c2md20054f

Author

Goldberg, Kristin ; Groombridge, Sam ; Hudson, Julian et al. / Oxadiazole isomers : All bioisosteres are not created equal. In: MedChemComm. 2012 ; Vol. 3, No. 5. pp. 600-604.

Bibtex

@article{c86e7827d3174676baae6223b4c210be,
title = "Oxadiazole isomers: All bioisosteres are not created equal",
abstract = "Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.",
author = "Kristin Goldberg and Sam Groombridge and Julian Hudson and Leach, {Andrew G.} and MacFaul, {Philip A.} and Adrian Pickup and Ruth Poultney and Scott, {James S.} and Svensson, {Per H.} and Joseph Sweeney",
year = "2012",
month = may,
day = "1",
doi = "10.1039/c2md20054f",
language = "English",
volume = "3",
pages = "600--604",
journal = "MedChemComm",
issn = "2040-2503",
publisher = "Royal Society of Chemistry",
number = "5",

}

RIS

TY - JOUR

T1 - Oxadiazole isomers

T2 - All bioisosteres are not created equal

AU - Goldberg, Kristin

AU - Groombridge, Sam

AU - Hudson, Julian

AU - Leach, Andrew G.

AU - MacFaul, Philip A.

AU - Pickup, Adrian

AU - Poultney, Ruth

AU - Scott, James S.

AU - Svensson, Per H.

AU - Sweeney, Joseph

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.

AB - Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.

U2 - 10.1039/c2md20054f

DO - 10.1039/c2md20054f

M3 - Journal article

AN - SCOPUS:84860429692

VL - 3

SP - 600

EP - 604

JO - MedChemComm

JF - MedChemComm

SN - 2040-2503

IS - 5

ER -