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Pathophysiology of lymphatic drainage of the central nervous system: Implications for the pathophysiology of multiple sclerosis

Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter

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Pathophysiology of lymphatic drainage of the central nervous system: Implications for the pathophysiology of multiple sclerosis. / Weller, Roy O.; Carare, Roxana O.; Hawkes, Cheryl A. et al.
Multiple Sclerosis: A Mechanistic View. ed. / Alireza Minagar. Elsevier Inc., 2015. p. 479-501.

Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter

Harvard

Weller, RO, Carare, RO, Hawkes, CA & Galea, I 2015, Pathophysiology of lymphatic drainage of the central nervous system: Implications for the pathophysiology of multiple sclerosis. in A Minagar (ed.), Multiple Sclerosis: A Mechanistic View. Elsevier Inc., pp. 479-501. https://doi.org/10.1016/B978-0-12-800763-1.00019-1

APA

Weller, R. O., Carare, R. O., Hawkes, C. A., & Galea, I. (2015). Pathophysiology of lymphatic drainage of the central nervous system: Implications for the pathophysiology of multiple sclerosis. In A. Minagar (Ed.), Multiple Sclerosis: A Mechanistic View (pp. 479-501). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800763-1.00019-1

Vancouver

Weller RO, Carare RO, Hawkes CA, Galea I. Pathophysiology of lymphatic drainage of the central nervous system: Implications for the pathophysiology of multiple sclerosis. In Minagar A, editor, Multiple Sclerosis: A Mechanistic View. Elsevier Inc. 2015. p. 479-501 doi: 10.1016/B978-0-12-800763-1.00019-1

Author

Weller, Roy O. ; Carare, Roxana O. ; Hawkes, Cheryl A. et al. / Pathophysiology of lymphatic drainage of the central nervous system : Implications for the pathophysiology of multiple sclerosis. Multiple Sclerosis: A Mechanistic View. editor / Alireza Minagar. Elsevier Inc., 2015. pp. 479-501

Bibtex

@inbook{c28dd07792444d71bbc2b431bd11be43,
title = "Pathophysiology of lymphatic drainage of the central nervous system: Implications for the pathophysiology of multiple sclerosis",
abstract = "Autoimmune inflammation in the central nervous system (CNS) plays a significant role in multiple sclerosis (MS), suggesting that regional lymph nodes are involved in pathogenesis of the disease. The brain has two fluids that drain to lymph nodes: cerebrospinal fluid (CSF) and interstitial fluid (ISF). CSF drains via nasal lymphatics and carries antigens, antigen-presenting cells (APCs), and inflammatory cells to cervical lymph nodes (CLNs). There are no conventional lymphatics in the parenchyma of the CNS; instead, ISF and soluble antigens drain to lymph nodes along narrow basement membranes in the walls of capillaries and arteries. This route is too narrow to allow the migration of APCs. Lymphatic drainage of CSF and ISF appears to confer tolerance to CNS proteins upon the CLNs. Such tolerance may be eclipsed when systemic exposure to brain antigens primes lymphocytes against CNS antigens, as occurs in experimental autoimmune encephalomyelitis. Similar mechanisms may apply to the pathogenesis of MS.",
keywords = "Alzheimer's disease, Arteries, Basement membranes, Brain, CSF, Immunological tolerance, Interstitial fluid, Lymph nodes, Lymphatic drainage, Multiple sclerosis, Neuroimmunology",
author = "Weller, {Roy O.} and Carare, {Roxana O.} and Hawkes, {Cheryl A.} and Ian Galea",
year = "2015",
month = nov,
day = "20",
doi = "10.1016/B978-0-12-800763-1.00019-1",
language = "English",
isbn = "9780128007631",
pages = "479--501",
editor = "Alireza Minagar",
booktitle = "Multiple Sclerosis",
publisher = "Elsevier Inc.",
address = "United States",

}

RIS

TY - CHAP

T1 - Pathophysiology of lymphatic drainage of the central nervous system

T2 - Implications for the pathophysiology of multiple sclerosis

AU - Weller, Roy O.

AU - Carare, Roxana O.

AU - Hawkes, Cheryl A.

AU - Galea, Ian

PY - 2015/11/20

Y1 - 2015/11/20

N2 - Autoimmune inflammation in the central nervous system (CNS) plays a significant role in multiple sclerosis (MS), suggesting that regional lymph nodes are involved in pathogenesis of the disease. The brain has two fluids that drain to lymph nodes: cerebrospinal fluid (CSF) and interstitial fluid (ISF). CSF drains via nasal lymphatics and carries antigens, antigen-presenting cells (APCs), and inflammatory cells to cervical lymph nodes (CLNs). There are no conventional lymphatics in the parenchyma of the CNS; instead, ISF and soluble antigens drain to lymph nodes along narrow basement membranes in the walls of capillaries and arteries. This route is too narrow to allow the migration of APCs. Lymphatic drainage of CSF and ISF appears to confer tolerance to CNS proteins upon the CLNs. Such tolerance may be eclipsed when systemic exposure to brain antigens primes lymphocytes against CNS antigens, as occurs in experimental autoimmune encephalomyelitis. Similar mechanisms may apply to the pathogenesis of MS.

AB - Autoimmune inflammation in the central nervous system (CNS) plays a significant role in multiple sclerosis (MS), suggesting that regional lymph nodes are involved in pathogenesis of the disease. The brain has two fluids that drain to lymph nodes: cerebrospinal fluid (CSF) and interstitial fluid (ISF). CSF drains via nasal lymphatics and carries antigens, antigen-presenting cells (APCs), and inflammatory cells to cervical lymph nodes (CLNs). There are no conventional lymphatics in the parenchyma of the CNS; instead, ISF and soluble antigens drain to lymph nodes along narrow basement membranes in the walls of capillaries and arteries. This route is too narrow to allow the migration of APCs. Lymphatic drainage of CSF and ISF appears to confer tolerance to CNS proteins upon the CLNs. Such tolerance may be eclipsed when systemic exposure to brain antigens primes lymphocytes against CNS antigens, as occurs in experimental autoimmune encephalomyelitis. Similar mechanisms may apply to the pathogenesis of MS.

KW - Alzheimer's disease

KW - Arteries

KW - Basement membranes

KW - Brain

KW - CSF

KW - Immunological tolerance

KW - Interstitial fluid

KW - Lymph nodes

KW - Lymphatic drainage

KW - Multiple sclerosis

KW - Neuroimmunology

U2 - 10.1016/B978-0-12-800763-1.00019-1

DO - 10.1016/B978-0-12-800763-1.00019-1

M3 - Chapter

SN - 9780128007631

SP - 479

EP - 501

BT - Multiple Sclerosis

A2 - Minagar, Alireza

PB - Elsevier Inc.

ER -