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People with Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Exhibit Similarly Impaired Vascular Function

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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People with Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Exhibit Similarly Impaired Vascular Function. / Mclaughlin, Marie; Sanal-Hayes, Nilihan E.M.; Hayes, Lawrence D. et al.
In: American Journal of Medicine, 11.10.2023.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Mclaughlin, M, Sanal-Hayes, NEM, Hayes, LD, Berry, EC & Sculthorpe, NF 2023, 'People with Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Exhibit Similarly Impaired Vascular Function', American Journal of Medicine. https://doi.org/10.1016/j.amjmed.2023.09.013

APA

Mclaughlin, M., Sanal-Hayes, N. E. M., Hayes, L. D., Berry, E. C., & Sculthorpe, N. F. (2023). People with Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Exhibit Similarly Impaired Vascular Function. American Journal of Medicine. Advance online publication. https://doi.org/10.1016/j.amjmed.2023.09.013

Vancouver

Mclaughlin M, Sanal-Hayes NEM, Hayes LD, Berry EC, Sculthorpe NF. People with Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Exhibit Similarly Impaired Vascular Function. American Journal of Medicine. 2023 Oct 11. Epub 2023 Oct 11. doi: 10.1016/j.amjmed.2023.09.013

Author

Mclaughlin, Marie ; Sanal-Hayes, Nilihan E.M. ; Hayes, Lawrence D. et al. / People with Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Exhibit Similarly Impaired Vascular Function. In: American Journal of Medicine. 2023.

Bibtex

@article{b379cc9cc27b4805b214a36293ab641f,
title = "People with Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Exhibit Similarly Impaired Vascular Function",
abstract = "Background: This study aimed to compare flow-mediated dilation values between individuals with long COVID, individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and healthy age-matched controls to assess the potential implications for clinical management and long-term health outcomes. Methods: A case-case-control approach was employed, and flow-mediated dilation measurements were obtained from 51 participants (17 long COVID patients, 17 ME/CFS patients, and 17 healthy age-matched controls). Flow-mediated dilation values were analyzed using 1-way analysis of variance for between-group comparisons. Results: Results revealed significantly impaired endothelial function in both long COVID and ME/CFS groups compared with healthy age-matched controls as determined by maximum % brachial artery diameter post-occlusion compared with pre-occlusion resting diameter (6.99 ± 4.33% and 6.60 ± 3.48% vs 11.30 ± 4.44%, respectively, both P < .05). Notably, there was no difference in flow-mediated dilation between long COVID and ME/CFS groups (P = .949), despite significantly longer illness duration in the ME/CFS group (ME/CFS: 16 ± 11.15 years vs long COVID: 1.36 ± 0.51 years, P < .0001). Conclusion: The study demonstrates that both long COVID and ME/CFS patients exhibit similarly impaired endothelial function, indicating potential vascular involvement in the pathogenesis of these post-viral illnesses. The significant reduction in flow-mediated dilation values suggests an increased cardiovascular risk in these populations, warranting careful monitoring and the development of targeted interventions to improve endothelial function and mitigate long-term health implications.",
keywords = "Chronic fatigue syndrome, Flow-mediated dilation, Long COVID, Myalgic encephalomyelitis",
author = "Marie Mclaughlin and Sanal-Hayes, {Nilihan E.M.} and Hayes, {Lawrence D.} and Berry, {Ethan C.} and Sculthorpe, {Nicholas F.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
month = oct,
day = "11",
doi = "10.1016/j.amjmed.2023.09.013",
language = "English",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",

}

RIS

TY - JOUR

T1 - People with Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Exhibit Similarly Impaired Vascular Function

AU - Mclaughlin, Marie

AU - Sanal-Hayes, Nilihan E.M.

AU - Hayes, Lawrence D.

AU - Berry, Ethan C.

AU - Sculthorpe, Nicholas F.

N1 - Publisher Copyright: © 2023 The Authors

PY - 2023/10/11

Y1 - 2023/10/11

N2 - Background: This study aimed to compare flow-mediated dilation values between individuals with long COVID, individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and healthy age-matched controls to assess the potential implications for clinical management and long-term health outcomes. Methods: A case-case-control approach was employed, and flow-mediated dilation measurements were obtained from 51 participants (17 long COVID patients, 17 ME/CFS patients, and 17 healthy age-matched controls). Flow-mediated dilation values were analyzed using 1-way analysis of variance for between-group comparisons. Results: Results revealed significantly impaired endothelial function in both long COVID and ME/CFS groups compared with healthy age-matched controls as determined by maximum % brachial artery diameter post-occlusion compared with pre-occlusion resting diameter (6.99 ± 4.33% and 6.60 ± 3.48% vs 11.30 ± 4.44%, respectively, both P < .05). Notably, there was no difference in flow-mediated dilation between long COVID and ME/CFS groups (P = .949), despite significantly longer illness duration in the ME/CFS group (ME/CFS: 16 ± 11.15 years vs long COVID: 1.36 ± 0.51 years, P < .0001). Conclusion: The study demonstrates that both long COVID and ME/CFS patients exhibit similarly impaired endothelial function, indicating potential vascular involvement in the pathogenesis of these post-viral illnesses. The significant reduction in flow-mediated dilation values suggests an increased cardiovascular risk in these populations, warranting careful monitoring and the development of targeted interventions to improve endothelial function and mitigate long-term health implications.

AB - Background: This study aimed to compare flow-mediated dilation values between individuals with long COVID, individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and healthy age-matched controls to assess the potential implications for clinical management and long-term health outcomes. Methods: A case-case-control approach was employed, and flow-mediated dilation measurements were obtained from 51 participants (17 long COVID patients, 17 ME/CFS patients, and 17 healthy age-matched controls). Flow-mediated dilation values were analyzed using 1-way analysis of variance for between-group comparisons. Results: Results revealed significantly impaired endothelial function in both long COVID and ME/CFS groups compared with healthy age-matched controls as determined by maximum % brachial artery diameter post-occlusion compared with pre-occlusion resting diameter (6.99 ± 4.33% and 6.60 ± 3.48% vs 11.30 ± 4.44%, respectively, both P < .05). Notably, there was no difference in flow-mediated dilation between long COVID and ME/CFS groups (P = .949), despite significantly longer illness duration in the ME/CFS group (ME/CFS: 16 ± 11.15 years vs long COVID: 1.36 ± 0.51 years, P < .0001). Conclusion: The study demonstrates that both long COVID and ME/CFS patients exhibit similarly impaired endothelial function, indicating potential vascular involvement in the pathogenesis of these post-viral illnesses. The significant reduction in flow-mediated dilation values suggests an increased cardiovascular risk in these populations, warranting careful monitoring and the development of targeted interventions to improve endothelial function and mitigate long-term health implications.

KW - Chronic fatigue syndrome

KW - Flow-mediated dilation

KW - Long COVID

KW - Myalgic encephalomyelitis

U2 - 10.1016/j.amjmed.2023.09.013

DO - 10.1016/j.amjmed.2023.09.013

M3 - Journal article

C2 - 37832757

AN - SCOPUS:85176424526

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

ER -