Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Peutz-Jeghers syndrome and screening for pancreatic cancer
AU - Latchford, A.
AU - Greenhalf, W.
AU - Vitone, L. J.
AU - Neoptolemos, J. P.
AU - Lancaster, Gillian
AU - Phillips, R. K. S.
PY - 2006/12
Y1 - 2006/12
N2 - Background:Cancer risk, including pancreatic, is high in those with Peutz–Jeghers syndrome (PJS). It has been suggested that such patients should undergo screening for pancreatic cancer.Methods:The risk of pancreatic cancer in PJS, pancreatic screening and potential screening strategies were reviewed. Cost-effectiveness was assessed according to American Gastroenterology Association guidelines and a risk stratification model proposed by the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer.Results:The risk of pancreatic cancer is increased in PJS but screening would cost over US $350 000 per life saved. Risk stratification reduces cost by $100 000 and costs fall to $50 000 per life saved if deaths from other forms of cancer are avoided.Conclusion:Screening should be performed only on a research basis to evaluate the benefit and cost-effectiveness in high-risk groups
AB - Background:Cancer risk, including pancreatic, is high in those with Peutz–Jeghers syndrome (PJS). It has been suggested that such patients should undergo screening for pancreatic cancer.Methods:The risk of pancreatic cancer in PJS, pancreatic screening and potential screening strategies were reviewed. Cost-effectiveness was assessed according to American Gastroenterology Association guidelines and a risk stratification model proposed by the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer.Results:The risk of pancreatic cancer is increased in PJS but screening would cost over US $350 000 per life saved. Risk stratification reduces cost by $100 000 and costs fall to $50 000 per life saved if deaths from other forms of cancer are avoided.Conclusion:Screening should be performed only on a research basis to evaluate the benefit and cost-effectiveness in high-risk groups
U2 - 10.1002/bjs.5609
DO - 10.1002/bjs.5609
M3 - Journal article
C2 - 17115408
VL - 93
SP - 1446
EP - 1455
JO - British Journal of Surgery
JF - British Journal of Surgery
SN - 0007-1323
IS - 12
ER -