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Peutz-Jeghers syndrome and screening for pancreatic cancer

Research output: Contribution to journalJournal articlepeer-review

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Peutz-Jeghers syndrome and screening for pancreatic cancer. / Latchford, A.; Greenhalf, W.; Vitone, L. J.; Neoptolemos, J. P.; Lancaster, Gillian; Phillips, R. K. S.

In: British Journal of Surgery, Vol. 93, No. 12, 12.2006, p. 1446-1455.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Latchford, A, Greenhalf, W, Vitone, LJ, Neoptolemos, JP, Lancaster, G & Phillips, RKS 2006, 'Peutz-Jeghers syndrome and screening for pancreatic cancer', British Journal of Surgery, vol. 93, no. 12, pp. 1446-1455. https://doi.org/10.1002/bjs.5609

APA

Latchford, A., Greenhalf, W., Vitone, L. J., Neoptolemos, J. P., Lancaster, G., & Phillips, R. K. S. (2006). Peutz-Jeghers syndrome and screening for pancreatic cancer. British Journal of Surgery, 93(12), 1446-1455. https://doi.org/10.1002/bjs.5609

Vancouver

Latchford A, Greenhalf W, Vitone LJ, Neoptolemos JP, Lancaster G, Phillips RKS. Peutz-Jeghers syndrome and screening for pancreatic cancer. British Journal of Surgery. 2006 Dec;93(12):1446-1455. https://doi.org/10.1002/bjs.5609

Author

Latchford, A. ; Greenhalf, W. ; Vitone, L. J. ; Neoptolemos, J. P. ; Lancaster, Gillian ; Phillips, R. K. S. / Peutz-Jeghers syndrome and screening for pancreatic cancer. In: British Journal of Surgery. 2006 ; Vol. 93, No. 12. pp. 1446-1455.

Bibtex

@article{c56b4e29ebac46f8ab00373385625522,
title = "Peutz-Jeghers syndrome and screening for pancreatic cancer",
abstract = "Background:Cancer risk, including pancreatic, is high in those with Peutz–Jeghers syndrome (PJS). It has been suggested that such patients should undergo screening for pancreatic cancer.Methods:The risk of pancreatic cancer in PJS, pancreatic screening and potential screening strategies were reviewed. Cost-effectiveness was assessed according to American Gastroenterology Association guidelines and a risk stratification model proposed by the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer.Results:The risk of pancreatic cancer is increased in PJS but screening would cost over US $350 000 per life saved. Risk stratification reduces cost by $100 000 and costs fall to $50 000 per life saved if deaths from other forms of cancer are avoided.Conclusion:Screening should be performed only on a research basis to evaluate the benefit and cost-effectiveness in high-risk groups",
author = "A. Latchford and W. Greenhalf and Vitone, {L. J.} and Neoptolemos, {J. P.} and Gillian Lancaster and Phillips, {R. K. S.}",
year = "2006",
month = dec,
doi = "10.1002/bjs.5609",
language = "English",
volume = "93",
pages = "1446--1455",
journal = "British Journal of Surgery",
issn = "0007-1323",
publisher = "John Wiley and Sons Ltd",
number = "12",

}

RIS

TY - JOUR

T1 - Peutz-Jeghers syndrome and screening for pancreatic cancer

AU - Latchford, A.

AU - Greenhalf, W.

AU - Vitone, L. J.

AU - Neoptolemos, J. P.

AU - Lancaster, Gillian

AU - Phillips, R. K. S.

PY - 2006/12

Y1 - 2006/12

N2 - Background:Cancer risk, including pancreatic, is high in those with Peutz–Jeghers syndrome (PJS). It has been suggested that such patients should undergo screening for pancreatic cancer.Methods:The risk of pancreatic cancer in PJS, pancreatic screening and potential screening strategies were reviewed. Cost-effectiveness was assessed according to American Gastroenterology Association guidelines and a risk stratification model proposed by the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer.Results:The risk of pancreatic cancer is increased in PJS but screening would cost over US $350 000 per life saved. Risk stratification reduces cost by $100 000 and costs fall to $50 000 per life saved if deaths from other forms of cancer are avoided.Conclusion:Screening should be performed only on a research basis to evaluate the benefit and cost-effectiveness in high-risk groups

AB - Background:Cancer risk, including pancreatic, is high in those with Peutz–Jeghers syndrome (PJS). It has been suggested that such patients should undergo screening for pancreatic cancer.Methods:The risk of pancreatic cancer in PJS, pancreatic screening and potential screening strategies were reviewed. Cost-effectiveness was assessed according to American Gastroenterology Association guidelines and a risk stratification model proposed by the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer.Results:The risk of pancreatic cancer is increased in PJS but screening would cost over US $350 000 per life saved. Risk stratification reduces cost by $100 000 and costs fall to $50 000 per life saved if deaths from other forms of cancer are avoided.Conclusion:Screening should be performed only on a research basis to evaluate the benefit and cost-effectiveness in high-risk groups

U2 - 10.1002/bjs.5609

DO - 10.1002/bjs.5609

M3 - Journal article

C2 - 17115408

VL - 93

SP - 1446

EP - 1455

JO - British Journal of Surgery

JF - British Journal of Surgery

SN - 0007-1323

IS - 12

ER -