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Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter (peer-reviewed) › peer-review
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter (peer-reviewed) › peer-review
}
TY - CHAP
T1 - Phase coherence between cardiovascular oscillations in malaria
T2 - the basis for a possible diagnostic test
AU - Abdulhameed , Yunus A.
AU - Habib, Abdulrazaq G.
AU - McClintock, Peter V. E.
AU - Stefanovska, Aneta
N1 - The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-030-59805-1_26
PY - 2021/5/6
Y1 - 2021/5/6
N2 - We show how a non-autonomous dynamics approach using time-resolved analyses of power spectra and phase coherence can help in the noninvasive diagnosis of malaria. The work is based on studying oscillations in blood flow and the variability of the heart and respiratory frequencies. The model used assumes that the heart and respiration are two oscillatory pumps with variable frequencies and that the vascular resistance also changes in an oscillatory manner. Red blood cells circulating through the system deliver oxygen to each cell. Malaria changes the red blood cells so that this delivery is compromised. The oscillatory properties of both pumps are also affected. We quantify the latter and compare three groups of subjects: febrile malaria patients (37); non-febrile malaria patients (10); and healthy controls (51). For each subject, time series of skin blood flow, respiratory effort, cardiac activity (ECG) and skin temperature were recorded simultaneously over an interval of 30 minutes. The oscillatory components within the range 0.005–2 Hz were analysed and their degree of coordination throughout the cardiovascular system was assessed by wavelet phase coherence analysis. It is shown that malaria, either febrile or non-febrile, substantially reduces the coordination.
AB - We show how a non-autonomous dynamics approach using time-resolved analyses of power spectra and phase coherence can help in the noninvasive diagnosis of malaria. The work is based on studying oscillations in blood flow and the variability of the heart and respiratory frequencies. The model used assumes that the heart and respiration are two oscillatory pumps with variable frequencies and that the vascular resistance also changes in an oscillatory manner. Red blood cells circulating through the system deliver oxygen to each cell. Malaria changes the red blood cells so that this delivery is compromised. The oscillatory properties of both pumps are also affected. We quantify the latter and compare three groups of subjects: febrile malaria patients (37); non-febrile malaria patients (10); and healthy controls (51). For each subject, time series of skin blood flow, respiratory effort, cardiac activity (ECG) and skin temperature were recorded simultaneously over an interval of 30 minutes. The oscillatory components within the range 0.005–2 Hz were analysed and their degree of coordination throughout the cardiovascular system was assessed by wavelet phase coherence analysis. It is shown that malaria, either febrile or non-febrile, substantially reduces the coordination.
U2 - 10.1007/978-3-030-59805-1_26
DO - 10.1007/978-3-030-59805-1_26
M3 - Chapter (peer-reviewed)
SN - 9783030598044
T3 - Understanding Complex Systems
SP - 401
EP - 419
BT - Physics of Biological Oscillators
A2 - Stefanovska, Aneta
A2 - McClintock, Peter V. E.
PB - Springer
CY - Cham
ER -