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Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene

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  • David R. Chisholm
  • Rebecca Lamb
  • Tommy Pallett
  • Valerie Affleck
  • Claire Holden
  • Joanne Marrison
  • Peter O'Toole
  • Peter D. Ashton
  • Katherine Newling
  • Andreas Steffen
  • Amanda K. Nelson
  • Christoph Mahler
  • Roy Valentine
  • Thomas S. Blacker
  • Angus J. Bain
  • John Girkin
  • Todd B. Marder
  • Andrew Whiting
  • Carrie A. Ambler
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<mark>Journal publication date</mark>7/05/2019
<mark>Journal</mark>Chemical Science
Issue number17
Volume10
Number of pages11
Pages (from-to)4673-4683
Publication StatusPublished
Early online date21/03/19
<mark>Original language</mark>English

Abstract

Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of diseased tissues and tumours. A novel class of photosensitiser, exemplified by DC324, has been designed possessing a modular, low molecular weight and ‘drug-like’ structure which is bioavailable and can be photoactivated by UV-A/405 nm or corresponding two-photon absorption of near-IR (800 nm) light, resulting in powerful cytotoxic activity, ostensibly through the production of ROS in a cellular environment. A variety of in vitro cellular assays confirmed ROS formation and in vivo cytotoxic activity was exemplified via irradiation and subsequent targeted destruction of specific areas of a zebrafish embryo.