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Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene. / Chisholm, David R.; Lamb, Rebecca; Pallett, Tommy et al.
In: Chemical Science, Vol. 10, No. 17, 07.05.2019, p. 4673-4683.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Chisholm, DR, Lamb, R, Pallett, T, Affleck, V, Holden, C, Marrison, J, O'Toole, P, Ashton, PD, Newling, K, Steffen, A, Nelson, AK, Mahler, C, Valentine, R, Blacker, TS, Bain, AJ, Girkin, J, Marder, TB, Whiting, A & Ambler, CA 2019, 'Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene', Chemical Science, vol. 10, no. 17, pp. 4673-4683. https://doi.org/10.1039/c9sc00199a

APA

Chisholm, D. R., Lamb, R., Pallett, T., Affleck, V., Holden, C., Marrison, J., O'Toole, P., Ashton, P. D., Newling, K., Steffen, A., Nelson, A. K., Mahler, C., Valentine, R., Blacker, T. S., Bain, A. J., Girkin, J., Marder, T. B., Whiting, A., & Ambler, C. A. (2019). Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene. Chemical Science, 10(17), 4673-4683. https://doi.org/10.1039/c9sc00199a

Vancouver

Chisholm DR, Lamb R, Pallett T, Affleck V, Holden C, Marrison J et al. Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene. Chemical Science. 2019 May 7;10(17):4673-4683. Epub 2019 Mar 21. doi: 10.1039/c9sc00199a

Author

Chisholm, David R. ; Lamb, Rebecca ; Pallett, Tommy et al. / Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene. In: Chemical Science. 2019 ; Vol. 10, No. 17. pp. 4673-4683.

Bibtex

@article{d0787609c50840d09867933834acffb0,
title = "Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene",
abstract = "Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of diseased tissues and tumours. A novel class of photosensitiser, exemplified by DC324, has been designed possessing a modular, low molecular weight and {\textquoteleft}drug-like{\textquoteright} structure which is bioavailable and can be photoactivated by UV-A/405 nm or corresponding two-photon absorption of near-IR (800 nm) light, resulting in powerful cytotoxic activity, ostensibly through the production of ROS in a cellular environment. A variety of in vitro cellular assays confirmed ROS formation and in vivo cytotoxic activity was exemplified via irradiation and subsequent targeted destruction of specific areas of a zebrafish embryo.",
author = "Chisholm, {David R.} and Rebecca Lamb and Tommy Pallett and Valerie Affleck and Claire Holden and Joanne Marrison and Peter O'Toole and Ashton, {Peter D.} and Katherine Newling and Andreas Steffen and Nelson, {Amanda K.} and Christoph Mahler and Roy Valentine and Blacker, {Thomas S.} and Bain, {Angus J.} and John Girkin and Marder, {Todd B.} and Andrew Whiting and Ambler, {Carrie A.}",
year = "2019",
month = may,
day = "7",
doi = "10.1039/c9sc00199a",
language = "English",
volume = "10",
pages = "4673--4683",
journal = "Chemical Science",
issn = "2041-6520",
publisher = "Royal Society of Chemistry",
number = "17",

}

RIS

TY - JOUR

T1 - Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene

AU - Chisholm, David R.

AU - Lamb, Rebecca

AU - Pallett, Tommy

AU - Affleck, Valerie

AU - Holden, Claire

AU - Marrison, Joanne

AU - O'Toole, Peter

AU - Ashton, Peter D.

AU - Newling, Katherine

AU - Steffen, Andreas

AU - Nelson, Amanda K.

AU - Mahler, Christoph

AU - Valentine, Roy

AU - Blacker, Thomas S.

AU - Bain, Angus J.

AU - Girkin, John

AU - Marder, Todd B.

AU - Whiting, Andrew

AU - Ambler, Carrie A.

PY - 2019/5/7

Y1 - 2019/5/7

N2 - Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of diseased tissues and tumours. A novel class of photosensitiser, exemplified by DC324, has been designed possessing a modular, low molecular weight and ‘drug-like’ structure which is bioavailable and can be photoactivated by UV-A/405 nm or corresponding two-photon absorption of near-IR (800 nm) light, resulting in powerful cytotoxic activity, ostensibly through the production of ROS in a cellular environment. A variety of in vitro cellular assays confirmed ROS formation and in vivo cytotoxic activity was exemplified via irradiation and subsequent targeted destruction of specific areas of a zebrafish embryo.

AB - Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of diseased tissues and tumours. A novel class of photosensitiser, exemplified by DC324, has been designed possessing a modular, low molecular weight and ‘drug-like’ structure which is bioavailable and can be photoactivated by UV-A/405 nm or corresponding two-photon absorption of near-IR (800 nm) light, resulting in powerful cytotoxic activity, ostensibly through the production of ROS in a cellular environment. A variety of in vitro cellular assays confirmed ROS formation and in vivo cytotoxic activity was exemplified via irradiation and subsequent targeted destruction of specific areas of a zebrafish embryo.

U2 - 10.1039/c9sc00199a

DO - 10.1039/c9sc00199a

M3 - Journal article

VL - 10

SP - 4673

EP - 4683

JO - Chemical Science

JF - Chemical Science

SN - 2041-6520

IS - 17

ER -