Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Physics of cellular energy metabolism
AU - Barnes, S.J.K.
AU - Stefanovska, A.
PY - 2022/9/30
Y1 - 2022/9/30
N2 - Contributions to the field of cellular energy metabolism have been dominated by biochemistry. Over the past decade, however, several physics-based approaches have been introduced. Oscillations are an intrinsic aspect of all living systems, from fluctuating substrate levels within cells to changes in electrical potential across membranes. Utilising physics-based approaches to analyse these time-dependent signals reveals pockets of predictable stability. By embracing the nonlinear, time-varying and open nature of cellular dynamics, new network-based approaches to modelling cells are emerging, capable of effectively replicating measured time-series data. These new approaches promise to bring greater comprehension of how various illnesses affect the cells, and indeed, to novel treatments or diagnostic methods.
AB - Contributions to the field of cellular energy metabolism have been dominated by biochemistry. Over the past decade, however, several physics-based approaches have been introduced. Oscillations are an intrinsic aspect of all living systems, from fluctuating substrate levels within cells to changes in electrical potential across membranes. Utilising physics-based approaches to analyse these time-dependent signals reveals pockets of predictable stability. By embracing the nonlinear, time-varying and open nature of cellular dynamics, new network-based approaches to modelling cells are emerging, capable of effectively replicating measured time-series data. These new approaches promise to bring greater comprehension of how various illnesses affect the cells, and indeed, to novel treatments or diagnostic methods.
KW - metabolism
KW - networks
KW - non-autonomous
KW - nonlinear
KW - Synchronisation
U2 - 10.1080/00107514.2022.2073046
DO - 10.1080/00107514.2022.2073046
M3 - Journal article
VL - 62
SP - 125
EP - 143
JO - Contemporary Physics
JF - Contemporary Physics
SN - 0010-7514
IS - 3
ER -