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Platinum and gold catalysis: à la carte hydroamination of terminal activated allenes with azoles

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published
<mark>Journal publication date</mark>3/09/2019
<mark>Journal</mark>Organic Letters
Issue number18
Volume21
Number of pages6
Pages (from-to)7639-7644
Publication StatusPublished
<mark>Original language</mark>English

Abstract

Nucleophilic additions to allenes catalyzed by transition metals represent a powerful tool to get selective access to diverse structures with numerous applications. Reported here is a straightforward methodology to achieve selective addition of azoles to the proximal or distal carbon of activated allenes depending on the catalyst used, unravelling a gold-platinum bimetallic catalysis approach for the 1,3-double addition of azoles to activated allenes to give 1,3-bisazole derivatives, important scaf-fold in medicinal and organometallic chemistry.