TY - JOUR

T1 - Platinum and gold catalysis: à la carte hydroamination of terminal activated allenes with azoles

AU - Alonso, José Miguel

AU - Munoz-Herranz, Maria Paz

PY - 2019/9/3

Y1 - 2019/9/3

N2 - Nucleophilic additions to allenes catalyzed by transition metals represent a powerful tool to get selective access to diverse structures with numerous applications. Reported here is a straightforward methodology to achieve selective addition of azoles to the proximal or distal carbon of activated allenes depending on the catalyst used, unravelling a gold-platinum bimetallic catalysis approach for the 1,3-double addition of azoles to activated allenes to give 1,3-bisazole derivatives, important scaf-fold in medicinal and organometallic chemistry.

AB - Nucleophilic additions to allenes catalyzed by transition metals represent a powerful tool to get selective access to diverse structures with numerous applications. Reported here is a straightforward methodology to achieve selective addition of azoles to the proximal or distal carbon of activated allenes depending on the catalyst used, unravelling a gold-platinum bimetallic catalysis approach for the 1,3-double addition of azoles to activated allenes to give 1,3-bisazole derivatives, important scaf-fold in medicinal and organometallic chemistry.

KW - allenes

KW - azoles

KW - bimetallic catalysis

KW - gold

KW - platinum

U2 - 10.1021/acs.orglett.9b02949

DO - 10.1021/acs.orglett.9b02949

M3 - Journal article

VL - 21

SP - 7639

EP - 7644

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 18

ER -