Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Point-source modelling using matched case control data.
AU - Diggle, P. J.
AU - Morris, S. E.
AU - Wakefield, J. C.
PY - 2000
Y1 - 2000
N2 - We describe an extension to matched case-control studies of the parametric modelling framework developed by Diggle (1990) and Diggle and Rowlingson (1994) to investigate raised risk around putative sources of environmental pollution. We use a conditional likelihood approach for the family of risk functions considered in Diggle and Rowlingson (1994). We show that the likelihood surface that results from these models may be highly irregular, and provide a Bayesian analysis in which we investigate the posterior distribution using Markov chain Monte Carlo. An analysis of one-one matched data that were collected to investigate the relationship between respiratory disease and distance to roads in East London is presented.
AB - We describe an extension to matched case-control studies of the parametric modelling framework developed by Diggle (1990) and Diggle and Rowlingson (1994) to investigate raised risk around putative sources of environmental pollution. We use a conditional likelihood approach for the family of risk functions considered in Diggle and Rowlingson (1994). We show that the likelihood surface that results from these models may be highly irregular, and provide a Bayesian analysis in which we investigate the posterior distribution using Markov chain Monte Carlo. An analysis of one-one matched data that were collected to investigate the relationship between respiratory disease and distance to roads in East London is presented.
KW - Bayes factors
KW - Environmental epidemiology
KW - Point process modelling
KW - Point sources of risk
KW - Matched case-control studies
U2 - 10.1093/biostatistics/1.1.89
DO - 10.1093/biostatistics/1.1.89
M3 - Journal article
VL - 1
SP - 89
EP - 105
JO - Biostatistics
JF - Biostatistics
SN - 1468-4357
IS - 1
ER -