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Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release. / Sharma, Manoj; Kap, Özlem; Abdelmohsen, Hend et al.
In: Global Challenges, Vol. 7, No. 8, 2300002, 31.08.2023, p. 2300002.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Sharma, M, Kap, Ö, Abdelmohsen, H, Ashton, M, Harper, G, Firlak, M, Aaltonen, J, Bolland, K, Bragg, R, Deeley, S, Francis, E, Kazi, N, Mapley, B, Oikonomou, V, Aljohani, AD, Cheneler, D, Kılıç, V, Horzum, N & Hardy, J 2023, 'Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release', Global Challenges, vol. 7, no. 8, 2300002, pp. 2300002. https://doi.org/10.1002/gch2.202300002

APA

Sharma, M., Kap, Ö., Abdelmohsen, H., Ashton, M., Harper, G., Firlak, M., Aaltonen, J., Bolland, K., Bragg, R., Deeley, S., Francis, E., Kazi, N., Mapley, B., Oikonomou, V., Aljohani, A. D., Cheneler, D., Kılıç, V., Horzum, N., & Hardy, J. (2023). Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release. Global Challenges, 7(8), 2300002. Article 2300002. https://doi.org/10.1002/gch2.202300002

Vancouver

Sharma M, Kap Ö, Abdelmohsen H, Ashton M, Harper G, Firlak M et al. Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release. Global Challenges. 2023 Aug 31;7(8):2300002. 2300002. Epub 2023 Jul 5. doi: 10.1002/gch2.202300002

Author

Sharma, Manoj ; Kap, Özlem ; Abdelmohsen, Hend et al. / Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release. In: Global Challenges. 2023 ; Vol. 7, No. 8. pp. 2300002.

Bibtex

@article{98f2789ec41c46a5b48b29a389938352,
title = "Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release",
abstract = "The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ≈40 N). Swelling experiments conducted at 20, 35, and 60 °C show temperature-dependent degrees of swelling and diffusion kinetics. Drug release from the pHEMA hydrogel-based microneedles is fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc.",
keywords = "aging, cancer, diabetes, drug delivery, hydrogels, microneedles",
author = "Manoj Sharma and {\"O}zlem Kap and Hend Abdelmohsen and Mark Ashton and Garry Harper and Melike Firlak and Jasmine Aaltonen and Kerry Bolland and Ryan Bragg and Sarah Deeley and Ella Francis and Nahin Kazi and Bethany Mapley and Vasileios Oikonomou and Aljohani, {Amal Dhaifallah} and David Cheneler and Volkan Kılı{\c c} and Nesrin Horzum and John Hardy",
year = "2023",
month = aug,
day = "31",
doi = "10.1002/gch2.202300002",
language = "English",
volume = "7",
pages = "2300002",
journal = "Global Challenges",
issn = "2056-6646",
publisher = "Wiley",
number = "8",

}

RIS

TY - JOUR

T1 - Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release

AU - Sharma, Manoj

AU - Kap, Özlem

AU - Abdelmohsen, Hend

AU - Ashton, Mark

AU - Harper, Garry

AU - Firlak, Melike

AU - Aaltonen, Jasmine

AU - Bolland, Kerry

AU - Bragg, Ryan

AU - Deeley, Sarah

AU - Francis, Ella

AU - Kazi, Nahin

AU - Mapley, Bethany

AU - Oikonomou, Vasileios

AU - Aljohani, Amal Dhaifallah

AU - Cheneler, David

AU - Kılıç, Volkan

AU - Horzum, Nesrin

AU - Hardy, John

PY - 2023/8/31

Y1 - 2023/8/31

N2 - The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ≈40 N). Swelling experiments conducted at 20, 35, and 60 °C show temperature-dependent degrees of swelling and diffusion kinetics. Drug release from the pHEMA hydrogel-based microneedles is fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc.

AB - The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ≈40 N). Swelling experiments conducted at 20, 35, and 60 °C show temperature-dependent degrees of swelling and diffusion kinetics. Drug release from the pHEMA hydrogel-based microneedles is fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc.

KW - aging

KW - cancer

KW - diabetes

KW - drug delivery

KW - hydrogels

KW - microneedles

U2 - 10.1002/gch2.202300002

DO - 10.1002/gch2.202300002

M3 - Journal article

C2 - 37635699

VL - 7

SP - 2300002

JO - Global Challenges

JF - Global Challenges

SN - 2056-6646

IS - 8

M1 - 2300002

ER -