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Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells

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Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells. / Gola, Hannah; Engler, Harald; Sommershof, Annette et al.
In: BMC Psychiatry, Vol. 13, No. 1, 40, 31.01.2013.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Gola, H, Engler, H, Sommershof, A, Adenauer, H, Kolassa, S, Schedlowski, M, Groettrup, M, Elbert, T & Kolassa, I-T 2013, 'Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells', BMC Psychiatry, vol. 13, no. 1, 40. https://doi.org/10.1186/1471-244X-13-40

APA

Gola, H., Engler, H., Sommershof, A., Adenauer, H., Kolassa, S., Schedlowski, M., Groettrup, M., Elbert, T., & Kolassa, I-T. (2013). Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells. BMC Psychiatry, 13(1), Article 40. https://doi.org/10.1186/1471-244X-13-40

Vancouver

Gola H, Engler H, Sommershof A, Adenauer H, Kolassa S, Schedlowski M et al. Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells. BMC Psychiatry. 2013 Jan 31;13(1):40. doi: 10.1186/1471-244X-13-40

Author

Gola, Hannah ; Engler, Harald ; Sommershof, Annette et al. / Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells. In: BMC Psychiatry. 2013 ; Vol. 13, No. 1.

Bibtex

@article{e768a2a97e44404b9039eaf08dfd95e8,
title = "Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells",
abstract = "BackgroundPosttraumatic stress disorder (PTSD) is associated with an enhanced risk for cardiovascular and other inflammatory diseases. Chronic low-level inflammation has been suggested as a potential mechanism linking these conditions.MethodsWe investigated plasma cytokine levels as well as spontaneous and lipopolysaccharide (LPS)-stimulated cytokine production by peripheral blood mononuclear cells (PBMCs) in a group of 35 severely traumatized PTSD patients compared to 25 healthy controls.ResultsSpontaneous production of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α by isolated PBMCs was significantly higher in the PTSD compared to the control group and even correlated with PTSD symptom severity within the PTSD group. In contrast, circulating plasma levels of pro- and anti-inflammatory cytokines such as IL-6, IL-8, IL-10, TNF-α, or monocyte chemotactic protein (MCP)-1 were not significantly altered in PTSD patients compared to healthy controls.ConclusionsOur findings indicate that PBMCs of PTSD patients are already pre-activated in vivo, providing further evidence for low-grade inflammation in PTSD. This might possibly represent one psychobiological pathway from PTSD to poor physical health.",
author = "Hannah Gola and Harald Engler and Annette Sommershof and Hannah Adenauer and Stephan Kolassa and Manfred Schedlowski and Marcus Groettrup and Thomas Elbert and Iris-Tatjana Kolassa",
year = "2013",
month = jan,
day = "31",
doi = "10.1186/1471-244X-13-40",
language = "English",
volume = "13",
journal = "BMC Psychiatry",
issn = "1471-244X",
publisher = "NLM (Medline)",
number = "1",

}

RIS

TY - JOUR

T1 - Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells

AU - Gola, Hannah

AU - Engler, Harald

AU - Sommershof, Annette

AU - Adenauer, Hannah

AU - Kolassa, Stephan

AU - Schedlowski, Manfred

AU - Groettrup, Marcus

AU - Elbert, Thomas

AU - Kolassa, Iris-Tatjana

PY - 2013/1/31

Y1 - 2013/1/31

N2 - BackgroundPosttraumatic stress disorder (PTSD) is associated with an enhanced risk for cardiovascular and other inflammatory diseases. Chronic low-level inflammation has been suggested as a potential mechanism linking these conditions.MethodsWe investigated plasma cytokine levels as well as spontaneous and lipopolysaccharide (LPS)-stimulated cytokine production by peripheral blood mononuclear cells (PBMCs) in a group of 35 severely traumatized PTSD patients compared to 25 healthy controls.ResultsSpontaneous production of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α by isolated PBMCs was significantly higher in the PTSD compared to the control group and even correlated with PTSD symptom severity within the PTSD group. In contrast, circulating plasma levels of pro- and anti-inflammatory cytokines such as IL-6, IL-8, IL-10, TNF-α, or monocyte chemotactic protein (MCP)-1 were not significantly altered in PTSD patients compared to healthy controls.ConclusionsOur findings indicate that PBMCs of PTSD patients are already pre-activated in vivo, providing further evidence for low-grade inflammation in PTSD. This might possibly represent one psychobiological pathway from PTSD to poor physical health.

AB - BackgroundPosttraumatic stress disorder (PTSD) is associated with an enhanced risk for cardiovascular and other inflammatory diseases. Chronic low-level inflammation has been suggested as a potential mechanism linking these conditions.MethodsWe investigated plasma cytokine levels as well as spontaneous and lipopolysaccharide (LPS)-stimulated cytokine production by peripheral blood mononuclear cells (PBMCs) in a group of 35 severely traumatized PTSD patients compared to 25 healthy controls.ResultsSpontaneous production of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α by isolated PBMCs was significantly higher in the PTSD compared to the control group and even correlated with PTSD symptom severity within the PTSD group. In contrast, circulating plasma levels of pro- and anti-inflammatory cytokines such as IL-6, IL-8, IL-10, TNF-α, or monocyte chemotactic protein (MCP)-1 were not significantly altered in PTSD patients compared to healthy controls.ConclusionsOur findings indicate that PBMCs of PTSD patients are already pre-activated in vivo, providing further evidence for low-grade inflammation in PTSD. This might possibly represent one psychobiological pathway from PTSD to poor physical health.

U2 - 10.1186/1471-244X-13-40

DO - 10.1186/1471-244X-13-40

M3 - Journal article

VL - 13

JO - BMC Psychiatry

JF - BMC Psychiatry

SN - 1471-244X

IS - 1

M1 - 40

ER -