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Predicting the Efficacy of Stalk Cells Following Leading Cells Through a Micro-Channel Using Morphoelasticity and a Cell Shape Evolution Model

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Publication date30/07/2022
Host publicationComputer Methods, Imaging and Visualization in Biomechanics and Biomedical Engineering II : Selected Papers from the 17th International Symposium CMBBE and 5th Conference on Imaging and Visualization, September 7-9, 2021
EditorsJoão Manuel R. S. Tavares, Christoph Bourauel, Liesbet Geris, Jos Vander Slote
Place of PublicationCham
PublisherSpringer
Pages112-122
Number of pages11
<mark>Original language</mark>English

Publication series

NameLecture Notes in Computational Vision and Biomechanics
Volume38
ISSN (Print)2212-9391
ISSN (electronic)2212-9413

Abstract

Cancer cell migration between different body parts is the driving force behind cancer metastasis, which causes mortality of patients. Migration of cancer cells often proceeds by penetration through narrow cavities in possibly stiff tissues. In our previous work [12], a model for the evolution of cell geometry is developed, and in the current study we use this model to investigate whether followers among (cancer) cells benefit from leading (cancer) cells during transmigration through micro-channels and cavities. Using Wilcoxon’s signed-rank text on the data collected from Monte Carlo simulations, we conclude that the transmigration time for the stalk cell is significantly smaller than for the leading cell with a p-value less than 0.0001, for the modelling set-up that we have used in this study.