Final published version
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review
Publication date | 30/07/2022 |
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Host publication | Computer Methods, Imaging and Visualization in Biomechanics and Biomedical Engineering II : Selected Papers from the 17th International Symposium CMBBE and 5th Conference on Imaging and Visualization, September 7-9, 2021 |
Editors | João Manuel R. S. Tavares, Christoph Bourauel, Liesbet Geris, Jos Vander Slote |
Place of Publication | Cham |
Publisher | Springer |
Pages | 112-122 |
Number of pages | 11 |
<mark>Original language</mark> | English |
Name | Lecture Notes in Computational Vision and Biomechanics |
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Volume | 38 |
ISSN (Print) | 2212-9391 |
ISSN (electronic) | 2212-9413 |
Cancer cell migration between different body parts is the driving force behind cancer metastasis, which causes mortality of patients. Migration of cancer cells often proceeds by penetration through narrow cavities in possibly stiff tissues. In our previous work [12], a model for the evolution of cell geometry is developed, and in the current study we use this model to investigate whether followers among (cancer) cells benefit from leading (cancer) cells during transmigration through micro-channels and cavities. Using Wilcoxon’s signed-rank text on the data collected from Monte Carlo simulations, we conclude that the transmigration time for the stalk cell is significantly smaller than for the leading cell with a p-value less than 0.0001, for the modelling set-up that we have used in this study.