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Prediction of product morphology of lyophilized drugs in the case of Vacuum Induced Surface Freezing

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Prediction of product morphology of lyophilized drugs in the case of Vacuum Induced Surface Freezing. / Pisano, Roberto; Capozzi, Luigi C.
In: Chemical Engineering Research and Design, Vol. 125, 02.09.2017, p. 119-129.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Pisano, R & Capozzi, LC 2017, 'Prediction of product morphology of lyophilized drugs in the case of Vacuum Induced Surface Freezing', Chemical Engineering Research and Design, vol. 125, pp. 119-129. https://doi.org/10.1016/j.cherd.2017.07.004

APA

Pisano, R., & Capozzi, L. C. (2017). Prediction of product morphology of lyophilized drugs in the case of Vacuum Induced Surface Freezing. Chemical Engineering Research and Design, 125, 119-129. https://doi.org/10.1016/j.cherd.2017.07.004

Vancouver

Pisano R, Capozzi LC. Prediction of product morphology of lyophilized drugs in the case of Vacuum Induced Surface Freezing. Chemical Engineering Research and Design. 2017 Sept 2;125:119-129. doi: 10.1016/j.cherd.2017.07.004

Author

Pisano, Roberto ; Capozzi, Luigi C. / Prediction of product morphology of lyophilized drugs in the case of Vacuum Induced Surface Freezing. In: Chemical Engineering Research and Design. 2017 ; Vol. 125. pp. 119-129.

Bibtex

@article{d13c46cf4c0843f0a4201390a9e4505a,
title = "Prediction of product morphology of lyophilized drugs in the case of Vacuum Induced Surface Freezing",
abstract = "In pharmaceutical industry, freeze-drying is often used to produce protein therapeutics that are stable during shipping and long-term storage. The design of adequate freezing process is a crucial aspect to be considered as influences the final morphology and, hence, physicochemical properties of the lyophilized product. In this study, a mechanistic model is developed for better understanding the relationship between morphology of lyophilized samples and freezing conditions. More specifically, we focus on Vacuum Induced Surface Freezing that is a recent, promising technology that allows a precise control of temperature of nucleation. Model simulations were validated by comparison with the lyophilized product morphology as observed by Scanning Electron Microscopy. The model was found to give accurate results for two liquid formulations, containing mannitol and sucrose, and varying nucleation temperature.",
keywords = "Control, Freeze-drying, Freezing, Modelling, Pharmaceuticals, Vacuum Induced Surface Freezing",
author = "Roberto Pisano and Capozzi, {Luigi C.}",
year = "2017",
month = sep,
day = "2",
doi = "10.1016/j.cherd.2017.07.004",
language = "English",
volume = "125",
pages = "119--129",
journal = "Chemical Engineering Research and Design",
issn = "0263-8762",
publisher = "Institution of Chemical Engineers",

}

RIS

TY - JOUR

T1 - Prediction of product morphology of lyophilized drugs in the case of Vacuum Induced Surface Freezing

AU - Pisano, Roberto

AU - Capozzi, Luigi C.

PY - 2017/9/2

Y1 - 2017/9/2

N2 - In pharmaceutical industry, freeze-drying is often used to produce protein therapeutics that are stable during shipping and long-term storage. The design of adequate freezing process is a crucial aspect to be considered as influences the final morphology and, hence, physicochemical properties of the lyophilized product. In this study, a mechanistic model is developed for better understanding the relationship between morphology of lyophilized samples and freezing conditions. More specifically, we focus on Vacuum Induced Surface Freezing that is a recent, promising technology that allows a precise control of temperature of nucleation. Model simulations were validated by comparison with the lyophilized product morphology as observed by Scanning Electron Microscopy. The model was found to give accurate results for two liquid formulations, containing mannitol and sucrose, and varying nucleation temperature.

AB - In pharmaceutical industry, freeze-drying is often used to produce protein therapeutics that are stable during shipping and long-term storage. The design of adequate freezing process is a crucial aspect to be considered as influences the final morphology and, hence, physicochemical properties of the lyophilized product. In this study, a mechanistic model is developed for better understanding the relationship between morphology of lyophilized samples and freezing conditions. More specifically, we focus on Vacuum Induced Surface Freezing that is a recent, promising technology that allows a precise control of temperature of nucleation. Model simulations were validated by comparison with the lyophilized product morphology as observed by Scanning Electron Microscopy. The model was found to give accurate results for two liquid formulations, containing mannitol and sucrose, and varying nucleation temperature.

KW - Control

KW - Freeze-drying

KW - Freezing

KW - Modelling

KW - Pharmaceuticals

KW - Vacuum Induced Surface Freezing

U2 - 10.1016/j.cherd.2017.07.004

DO - 10.1016/j.cherd.2017.07.004

M3 - Journal article

AN - SCOPUS:85025157867

VL - 125

SP - 119

EP - 129

JO - Chemical Engineering Research and Design

JF - Chemical Engineering Research and Design

SN - 0263-8762

ER -