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Prednisolone reduces preconceptual endometrial natural killer cells in women with recurrent miscarriage.

Research output: Contribution to journalJournal articlepeer-review

  • Siobhan Quenby
  • Chimwemwe Kalumbi
  • Michelle Bates
  • Roy Farquharson,
  • Gill S. Vince
<mark>Journal publication date</mark>1/10/2005
<mark>Journal</mark>Fertility and Sterility
Issue number4
Number of pages5
Pages (from-to)980-984
Publication StatusPublished
<mark>Original language</mark>English


Objective To test the hypothesis that high numbers of uterine natural killer (uNK) cells in the endometrium of women with recurrent miscarriage (RM) could be reduced with prednisolone. Design A before and after study. Setting A tertiary referral teaching hospital. Patient(s) Eighty-five women with idiopathic RM recruited from all over the UK and 18 women attending for sterilization (controls). Intervention(s) An endometrial sample was taken on day 21 ± 2 of the menstrual cycle. Immunohistochemistry was used to identify uNK (CD56+, CD16−, CD3−). Twenty-nine women with RM and >5% uNK agreed to take 20 mg oral prednisolone daily from day 1 to 21 of their menstrual cycle, when a second biopsy was obtained and analyzed. Main Outcome Measure(s) The percentage of stromal cells that were uNK. The normal range was defined using control samples as <5%. Result(s) Women with RM had significantly more uNK than the controls (P=.008). Prednisolone treatment significantly reduced the number of CD56 cells in the endometrium, from a median of 14% (before) to 9% (after) (P=.0004). Conclusion(s) We have demonstrated that high numbers of uNK in preimplantation endometrium of women with recurrent miscarriage can be reduced with administration of prednisolone.

Bibliographic note

RAE_import_type : Journal article RAE_uoa_type : Allied Health Professions and Studies