Rights statement: This is the author’s version of a work that was accepted for publication in Seizure. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Seizure, 29, 2015 DOI: 10.1016/j.seizure.2015.03.016
Accepted author manuscript, 801 KB, PDF document
Available under license: CC BY-NC-ND: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
Final published version
Research output: Contribution to Journal/Magazine › Literature review › peer-review
Research output: Contribution to Journal/Magazine › Literature review › peer-review
}
TY - JOUR
T1 - Prevalence of epilepsy among people with intellectual disabilities
T2 - a systematic review
AU - Robertson, Janet
AU - Hatton, Chris
AU - Emerson, Eric
AU - Baines, Susannah
N1 - This is the author’s version of a work that was accepted for publication in Seizure. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Seizure, 29, 2015 DOI: 10.1016/j.seizure.2015.03.016
PY - 2015/7
Y1 - 2015/7
N2 - Purpose: Epilepsy is more common in people with intellectual disabilities than in the general population. However, reported prevalence rates vary widely between studies. This systematic review aimed to provide a summary of prevalence studies and estimates of prevalence based on meta-analyses.Method: Studies were identified via electronic searches using Medline, Cinahl and PsycINFO and cross-citations. Information extracted from studies was tabulated. Prevalence rate estimates were pooled using random effects meta-analyses and subgroup analyses were conducted.Results: A total of 48 studies were included in the tabulation and 46 studies were included in meta-analyses. In general samples of people with intellectual disabilities, the pooled estimate from 38 studies was 22.2% (95% CI 19.6-25.1). Prevalence increased with increasing level of intellectual disability. For samples of people with Down syndrome, the pooled estimate from data in 13 studies was 12.4% (95% CI 9.1-16.7), decreasing to 10.3% (95% CI 8.4-12.6) following removal of two studies focusing on older people. Prevalence increased with age in people with Down syndrome and was particularly prevalent in those with Alzheimer's/dementia.Conclusion: Epilepsy is highly prevalent in people with intellectual disabilities. Services must be equipped with the skills and information needed to manage this condition. (C) 2015 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
AB - Purpose: Epilepsy is more common in people with intellectual disabilities than in the general population. However, reported prevalence rates vary widely between studies. This systematic review aimed to provide a summary of prevalence studies and estimates of prevalence based on meta-analyses.Method: Studies were identified via electronic searches using Medline, Cinahl and PsycINFO and cross-citations. Information extracted from studies was tabulated. Prevalence rate estimates were pooled using random effects meta-analyses and subgroup analyses were conducted.Results: A total of 48 studies were included in the tabulation and 46 studies were included in meta-analyses. In general samples of people with intellectual disabilities, the pooled estimate from 38 studies was 22.2% (95% CI 19.6-25.1). Prevalence increased with increasing level of intellectual disability. For samples of people with Down syndrome, the pooled estimate from data in 13 studies was 12.4% (95% CI 9.1-16.7), decreasing to 10.3% (95% CI 8.4-12.6) following removal of two studies focusing on older people. Prevalence increased with age in people with Down syndrome and was particularly prevalent in those with Alzheimer's/dementia.Conclusion: Epilepsy is highly prevalent in people with intellectual disabilities. Services must be equipped with the skills and information needed to manage this condition. (C) 2015 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
KW - Epilepsy
KW - Prevalence
KW - Intellectual disabilities
KW - Down syndrome
KW - MENTALLY-RETARDED CHILDREN
KW - HEALTH INTERVIEW SURVEY
KW - DOWN-SYNDROME
KW - PSYCHIATRIC-DISORDERS
KW - SERVICE IMPLICATIONS
KW - ADAPTIVE-BEHAVIOR
KW - GENERAL-PRACTICE
KW - ACTIVE EPILEPSY
KW - OLDER-ADULTS
KW - RETARDATION
U2 - 10.1016/j.seizure.2015.03.016
DO - 10.1016/j.seizure.2015.03.016
M3 - Literature review
VL - 29
SP - 46
EP - 62
JO - Seizure - European Journal of Epilepsy
JF - Seizure - European Journal of Epilepsy
SN - 1059-1311
ER -