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Putative GTPase GIMAP1 is critical for the development of mature B and T lymphocytes

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • Amy Saunders
  • Louise M C Webb
  • Michelle L Janas
  • Amanda Hutchings
  • John Pascall
  • Christine Carter
  • Nicholas Pugh
  • Geoff Morgan
  • Martin Turner
  • Geoffrey W Butcher
<mark>Journal publication date</mark>22/04/2010
Issue number16
Number of pages9
Pages (from-to)3249-57
Publication StatusPublished
<mark>Original language</mark>English


The guanosine triphosphatases (GTPases) of the immunity-associated protein (GIMAP) family of putative GTPases has been implicated in the regulation of T-lymphocyte development and survival. A mouse conditional knockout allele was generated for the immune GTPase gene GIMAP1. Homozygous loss of this allele under the influence of the lymphoid-expressed hCD2-iCre recombinase transgene led to severe (> 85%) deficiency of mature T lymphocytes and, unexpectedly, of mature B lymphocytes. By contrast there was little effect of GIMAP1 deletion on immature lymphocytes in either B or T lineages, although in vitro studies showed a shortening of the survival time of both immature and mature CD4(+) single-positive thymocytes. These findings show a vital requirement for GIMAP1 in mature lymphocyte development/survival and draw attention to the nonredundant roles of members of the GIMAP GTPase family in these processes.