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Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B

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Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes : DRD4, DAT1, DRD5, SNAP-25, and 5HT1B. / Mill, Jonathan; Xu, Xiaohui; Ronald, Angelica et al.

In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics , Vol. 133B, No. 1, 05.02.2005, p. 68-73.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Mill, J, Xu, X, Ronald, A, Curran, S, Price, T, Knight, J, Craig, I, Sham, P, Plomin, R & Asherson, P 2005, 'Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics , vol. 133B, no. 1, pp. 68-73. https://doi.org/10.1002/ajmg.b.30107

APA

Mill, J., Xu, X., Ronald, A., Curran, S., Price, T., Knight, J., Craig, I., Sham, P., Plomin, R., & Asherson, P. (2005). Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics , 133B(1), 68-73. https://doi.org/10.1002/ajmg.b.30107

Vancouver

Mill J, Xu X, Ronald A, Curran S, Price T, Knight J et al. Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 2005 Feb 5;133B(1):68-73. Epub 2004 Dec 2. doi: 10.1002/ajmg.b.30107

Author

Mill, Jonathan ; Xu, Xiaohui ; Ronald, Angelica et al. / Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes : DRD4, DAT1, DRD5, SNAP-25, and 5HT1B. In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 2005 ; Vol. 133B, No. 1. pp. 68-73.

Bibtex

@article{841510d01ca644888b930921f6a90892,
title = "Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B",
abstract = "It has been widely postulated that the categorical diagnosis of attention deficit hyperactivity disorder (ADHD) should be seen as the extreme end of a set of traits quantitatively distributed in the general population. A consequence of this is that the genes associated with DSM-IV ADHD should also influence these underlying traits in non-affected individuals. The aim of this study was to examine if specific candidate loci previously shown to be associated with DSM-IV ADHD, also act as quantitative trait loci (QTLs) for ADHD-symptoms in the general population. We have genotyped five candidate markers in a population-based sample of male dizygous twin-pairs (n = 329 pairs). We found little evidence to support a role for the previously-nominated alleles of a DRD4 VNTR, a 5HT1B SNP, or a microsatellite marker near to DRD5, in the distribution of ADHD-symptoms scores; however, we found some evidence to suggest that the DAT1 3'UTR VNTR and weak evidence that a microsatellite in SNAP-25 may have a role in continuous measures of ADHD-symptoms hyperactivity above and beyond their role in clinical ADHD.",
keywords = "Alleles, Attention Deficit Disorder with Hyperactivity, Child, Dopamine Plasma Membrane Transport Proteins, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Linkage Disequilibrium, Male, Membrane Glycoproteins, Membrane Proteins, Membrane Transport Proteins, Meta-Analysis as Topic, Nerve Tissue Proteins, Polymorphism, Genetic, Quantitative Trait Loci, Receptor, Serotonin, 5-HT1B, Receptors, Dopamine D1, Receptors, Dopamine D2, Receptors, Dopamine D4, Receptors, Dopamine D5, Synaptosomal-Associated Protein 25, Twins, Dizygotic",
author = "Jonathan Mill and Xiaohui Xu and Angelica Ronald and Sarah Curran and Tom Price and Jo Knight and Ian Craig and Pak Sham and Robert Plomin and Philip Asherson",
note = "(c) 2004 Wiley-Liss, Inc.",
year = "2005",
month = feb,
day = "5",
doi = "10.1002/ajmg.b.30107",
language = "English",
volume = "133B",
pages = "68--73",
journal = "American Journal of Medical Genetics Part B: Neuropsychiatric Genetics ",
issn = "1552-4841",
publisher = "Wiley-Liss Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes

T2 - DRD4, DAT1, DRD5, SNAP-25, and 5HT1B

AU - Mill, Jonathan

AU - Xu, Xiaohui

AU - Ronald, Angelica

AU - Curran, Sarah

AU - Price, Tom

AU - Knight, Jo

AU - Craig, Ian

AU - Sham, Pak

AU - Plomin, Robert

AU - Asherson, Philip

N1 - (c) 2004 Wiley-Liss, Inc.

PY - 2005/2/5

Y1 - 2005/2/5

N2 - It has been widely postulated that the categorical diagnosis of attention deficit hyperactivity disorder (ADHD) should be seen as the extreme end of a set of traits quantitatively distributed in the general population. A consequence of this is that the genes associated with DSM-IV ADHD should also influence these underlying traits in non-affected individuals. The aim of this study was to examine if specific candidate loci previously shown to be associated with DSM-IV ADHD, also act as quantitative trait loci (QTLs) for ADHD-symptoms in the general population. We have genotyped five candidate markers in a population-based sample of male dizygous twin-pairs (n = 329 pairs). We found little evidence to support a role for the previously-nominated alleles of a DRD4 VNTR, a 5HT1B SNP, or a microsatellite marker near to DRD5, in the distribution of ADHD-symptoms scores; however, we found some evidence to suggest that the DAT1 3'UTR VNTR and weak evidence that a microsatellite in SNAP-25 may have a role in continuous measures of ADHD-symptoms hyperactivity above and beyond their role in clinical ADHD.

AB - It has been widely postulated that the categorical diagnosis of attention deficit hyperactivity disorder (ADHD) should be seen as the extreme end of a set of traits quantitatively distributed in the general population. A consequence of this is that the genes associated with DSM-IV ADHD should also influence these underlying traits in non-affected individuals. The aim of this study was to examine if specific candidate loci previously shown to be associated with DSM-IV ADHD, also act as quantitative trait loci (QTLs) for ADHD-symptoms in the general population. We have genotyped five candidate markers in a population-based sample of male dizygous twin-pairs (n = 329 pairs). We found little evidence to support a role for the previously-nominated alleles of a DRD4 VNTR, a 5HT1B SNP, or a microsatellite marker near to DRD5, in the distribution of ADHD-symptoms scores; however, we found some evidence to suggest that the DAT1 3'UTR VNTR and weak evidence that a microsatellite in SNAP-25 may have a role in continuous measures of ADHD-symptoms hyperactivity above and beyond their role in clinical ADHD.

KW - Alleles

KW - Attention Deficit Disorder with Hyperactivity

KW - Child

KW - Dopamine Plasma Membrane Transport Proteins

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Linkage Disequilibrium

KW - Male

KW - Membrane Glycoproteins

KW - Membrane Proteins

KW - Membrane Transport Proteins

KW - Meta-Analysis as Topic

KW - Nerve Tissue Proteins

KW - Polymorphism, Genetic

KW - Quantitative Trait Loci

KW - Receptor, Serotonin, 5-HT1B

KW - Receptors, Dopamine D1

KW - Receptors, Dopamine D2

KW - Receptors, Dopamine D4

KW - Receptors, Dopamine D5

KW - Synaptosomal-Associated Protein 25

KW - Twins, Dizygotic

U2 - 10.1002/ajmg.b.30107

DO - 10.1002/ajmg.b.30107

M3 - Journal article

C2 - 15578613

VL - 133B

SP - 68

EP - 73

JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 1

ER -