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Rapid mechanosensitive migration and dispersal of newly divided mesenchymal cells aid their recruitment into dermal condensates

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Rapid mechanosensitive migration and dispersal of newly divided mesenchymal cells aid their recruitment into dermal condensates. / Riddell, Jon; Noureen, Shahzeb Raja; Sedda, Luigi et al.
In: Plos Biology, Vol. 21, No. 9, e3002316, 25.09.2023.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Riddell, J, Noureen, SR, Sedda, L, Glover, JD, Ho, WKW, Bain, CA, Berbeglia, A, Brown, H, Anderson, C, Chen, Y, Crichton, ML, Yates, CA, Mort, RL, Headon, DJ & Bronner, ME (ed.) 2023, 'Rapid mechanosensitive migration and dispersal of newly divided mesenchymal cells aid their recruitment into dermal condensates', Plos Biology, vol. 21, no. 9, e3002316. https://doi.org/10.1371/journal.pbio.3002316

APA

Riddell, J., Noureen, S. R., Sedda, L., Glover, J. D., Ho, W. K. W., Bain, C. A., Berbeglia, A., Brown, H., Anderson, C., Chen, Y., Crichton, M. L., Yates, C. A., Mort, R. L., Headon, D. J., & Bronner, M. E. (Ed.) (2023). Rapid mechanosensitive migration and dispersal of newly divided mesenchymal cells aid their recruitment into dermal condensates. Plos Biology, 21(9), Article e3002316. https://doi.org/10.1371/journal.pbio.3002316

Vancouver

Riddell J, Noureen SR, Sedda L, Glover JD, Ho WKW, Bain CA et al. Rapid mechanosensitive migration and dispersal of newly divided mesenchymal cells aid their recruitment into dermal condensates. Plos Biology. 2023 Sept 25;21(9):e3002316. doi: 10.1371/journal.pbio.3002316

Author

Riddell, Jon ; Noureen, Shahzeb Raja ; Sedda, Luigi et al. / Rapid mechanosensitive migration and dispersal of newly divided mesenchymal cells aid their recruitment into dermal condensates. In: Plos Biology. 2023 ; Vol. 21, No. 9.

Bibtex

@article{a55f2a9609ec4bd2bc2ed68c8015f454,
title = "Rapid mechanosensitive migration and dispersal of newly divided mesenchymal cells aid their recruitment into dermal condensates",
abstract = "Embryonic mesenchymal cells are dispersed within an extracellular matrix but can coalesce to form condensates with key developmental roles. Cells within condensates undergo fate and morphological changes and induce cell fate changes in nearby epithelia to produce structures including hair follicles, feathers, or intestinal villi. Here, by imaging mouse and chicken embryonic skin, we find that mesenchymal cells undergo much of their dispersal in early interphase, in a stereotyped process of displacement driven by 3 hours of rapid and persistent migration followed by a long period of low motility. The cell division plane and the elevated migration speed and persistence of newly born mesenchymal cells are mechanosensitive, aligning with tissue tension, and are reliant on active WNT secretion. This behaviour disperses mesenchymal cells and allows daughters of recent divisions to travel long distances to enter dermal condensates, demonstrating an unanticipated effect of cell cycle subphase on core mesenchymal behaviour.",
author = "Jon Riddell and Noureen, {Shahzeb Raja} and Luigi Sedda and Glover, {James D.} and Ho, {William K. W.} and Bain, {Connor A.} and Arianna Berbeglia and Helen Brown and Calum Anderson and Yuhang Chen and Crichton, {Michael L.} and Yates, {Christian A.} and Mort, {Richard L.} and Headon, {Denis J.} and Bronner, {Marianne E.}",
year = "2023",
month = sep,
day = "25",
doi = "10.1371/journal.pbio.3002316",
language = "English",
volume = "21",
journal = "Plos Biology",
issn = "1544-9173",
publisher = "Public Library of Science",
number = "9",

}

RIS

TY - JOUR

T1 - Rapid mechanosensitive migration and dispersal of newly divided mesenchymal cells aid their recruitment into dermal condensates

AU - Riddell, Jon

AU - Noureen, Shahzeb Raja

AU - Sedda, Luigi

AU - Glover, James D.

AU - Ho, William K. W.

AU - Bain, Connor A.

AU - Berbeglia, Arianna

AU - Brown, Helen

AU - Anderson, Calum

AU - Chen, Yuhang

AU - Crichton, Michael L.

AU - Yates, Christian A.

AU - Mort, Richard L.

AU - Headon, Denis J.

A2 - Bronner, Marianne E.

PY - 2023/9/25

Y1 - 2023/9/25

N2 - Embryonic mesenchymal cells are dispersed within an extracellular matrix but can coalesce to form condensates with key developmental roles. Cells within condensates undergo fate and morphological changes and induce cell fate changes in nearby epithelia to produce structures including hair follicles, feathers, or intestinal villi. Here, by imaging mouse and chicken embryonic skin, we find that mesenchymal cells undergo much of their dispersal in early interphase, in a stereotyped process of displacement driven by 3 hours of rapid and persistent migration followed by a long period of low motility. The cell division plane and the elevated migration speed and persistence of newly born mesenchymal cells are mechanosensitive, aligning with tissue tension, and are reliant on active WNT secretion. This behaviour disperses mesenchymal cells and allows daughters of recent divisions to travel long distances to enter dermal condensates, demonstrating an unanticipated effect of cell cycle subphase on core mesenchymal behaviour.

AB - Embryonic mesenchymal cells are dispersed within an extracellular matrix but can coalesce to form condensates with key developmental roles. Cells within condensates undergo fate and morphological changes and induce cell fate changes in nearby epithelia to produce structures including hair follicles, feathers, or intestinal villi. Here, by imaging mouse and chicken embryonic skin, we find that mesenchymal cells undergo much of their dispersal in early interphase, in a stereotyped process of displacement driven by 3 hours of rapid and persistent migration followed by a long period of low motility. The cell division plane and the elevated migration speed and persistence of newly born mesenchymal cells are mechanosensitive, aligning with tissue tension, and are reliant on active WNT secretion. This behaviour disperses mesenchymal cells and allows daughters of recent divisions to travel long distances to enter dermal condensates, demonstrating an unanticipated effect of cell cycle subphase on core mesenchymal behaviour.

U2 - 10.1371/journal.pbio.3002316

DO - 10.1371/journal.pbio.3002316

M3 - Journal article

VL - 21

JO - Plos Biology

JF - Plos Biology

SN - 1544-9173

IS - 9

M1 - e3002316

ER -