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Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • B.L. Patenall
  • G.T. Williams‡
  • L. Gwynne
  • L.J. Stephens
  • E.V. Lampard
  • H.J. Hathaway
  • N.T. Thet
  • A.E. Young
  • M.J. Sutton
  • R.D. Short
  • S.D. Bull
  • T.D. James
  • A.C. Sedgwick
  • A.T.A. Jenkins
<mark>Journal publication date</mark>28/12/2019
<mark>Journal</mark>Chemical Communications
Issue number100
Number of pages4
Pages (from-to)15129-15132
Publication StatusPublished
Early online date2/12/19
<mark>Original language</mark>English


Here, a reaction-based indicator displacement hydrogel assay (RIA) was developed for the detection of hydrogen peroxide (H2O2) via the oxidative release of the optical reporter Alizarin Red S (ARS). In the presence of H2O2, the RIA system displayed potent biofilm inhibition for Methicillin-resistant Staphylococcus aureus (MRSA), as shown through an in vitro assay quantifying antimicrobial efficacy. This work demonstrated the potential of H2O2-responsive hydrogels containing a covalently bound diol-based drug for controlled drug release.