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Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition. / Patenall, B.L.; Williams‡, G.T.; Gwynne, L. et al.
In: Chemical Communications, Vol. 55, No. 100, 28.12.2019, p. 15129-15132.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Patenall, BL, Williams‡, GT, Gwynne, L, Stephens, LJ, Lampard, EV, Hathaway, HJ, Thet, NT, Young, AE, Sutton, MJ, Short, RD, Bull, SD, James, TD, Sedgwick, AC & Jenkins, ATA 2019, 'Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition', Chemical Communications, vol. 55, no. 100, pp. 15129-15132. https://doi.org/10.1039/c9cc07759f

APA

Patenall, B. L., Williams‡, G. T., Gwynne, L., Stephens, L. J., Lampard, E. V., Hathaway, H. J., Thet, N. T., Young, A. E., Sutton, M. J., Short, R. D., Bull, S. D., James, T. D., Sedgwick, A. C., & Jenkins, A. T. A. (2019). Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition. Chemical Communications, 55(100), 15129-15132. https://doi.org/10.1039/c9cc07759f

Vancouver

Patenall BL, Williams‡ GT, Gwynne L, Stephens LJ, Lampard EV, Hathaway HJ et al. Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition. Chemical Communications. 2019 Dec 28;55(100):15129-15132. Epub 2019 Dec 2. doi: 10.1039/c9cc07759f

Author

Patenall, B.L. ; Williams‡, G.T. ; Gwynne, L. et al. / Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition. In: Chemical Communications. 2019 ; Vol. 55, No. 100. pp. 15129-15132.

Bibtex

@article{af56dff75d9e449aa49d91d072c10bba,
title = "Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition",
abstract = "Here, a reaction-based indicator displacement hydrogel assay (RIA) was developed for the detection of hydrogen peroxide (H2O2) via the oxidative release of the optical reporter Alizarin Red S (ARS). In the presence of H2O2, the RIA system displayed potent biofilm inhibition for Methicillin-resistant Staphylococcus aureus (MRSA), as shown through an in vitro assay quantifying antimicrobial efficacy. This work demonstrated the potential of H2O2-responsive hydrogels containing a covalently bound diol-based drug for controlled drug release.",
author = "B.L. Patenall and G.T. Williams‡ and L. Gwynne and L.J. Stephens and E.V. Lampard and H.J. Hathaway and N.T. Thet and A.E. Young and M.J. Sutton and R.D. Short and S.D. Bull and T.D. James and A.C. Sedgwick and A.T.A. Jenkins",
year = "2019",
month = dec,
day = "28",
doi = "10.1039/c9cc07759f",
language = "English",
volume = "55",
pages = "15129--15132",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "100",

}

RIS

TY - JOUR

T1 - Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition

AU - Patenall, B.L.

AU - Williams‡, G.T.

AU - Gwynne, L.

AU - Stephens, L.J.

AU - Lampard, E.V.

AU - Hathaway, H.J.

AU - Thet, N.T.

AU - Young, A.E.

AU - Sutton, M.J.

AU - Short, R.D.

AU - Bull, S.D.

AU - James, T.D.

AU - Sedgwick, A.C.

AU - Jenkins, A.T.A.

PY - 2019/12/28

Y1 - 2019/12/28

N2 - Here, a reaction-based indicator displacement hydrogel assay (RIA) was developed for the detection of hydrogen peroxide (H2O2) via the oxidative release of the optical reporter Alizarin Red S (ARS). In the presence of H2O2, the RIA system displayed potent biofilm inhibition for Methicillin-resistant Staphylococcus aureus (MRSA), as shown through an in vitro assay quantifying antimicrobial efficacy. This work demonstrated the potential of H2O2-responsive hydrogels containing a covalently bound diol-based drug for controlled drug release.

AB - Here, a reaction-based indicator displacement hydrogel assay (RIA) was developed for the detection of hydrogen peroxide (H2O2) via the oxidative release of the optical reporter Alizarin Red S (ARS). In the presence of H2O2, the RIA system displayed potent biofilm inhibition for Methicillin-resistant Staphylococcus aureus (MRSA), as shown through an in vitro assay quantifying antimicrobial efficacy. This work demonstrated the potential of H2O2-responsive hydrogels containing a covalently bound diol-based drug for controlled drug release.

U2 - 10.1039/c9cc07759f

DO - 10.1039/c9cc07759f

M3 - Journal article

VL - 55

SP - 15129

EP - 15132

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 100

ER -