Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Regulation of TGFβ in the immune system
T2 - an emerging role for integrins and dendritic cells
AU - Worthington, John J.
AU - Fenton, Thomas M.
AU - Czajkowska, Beata I.
AU - Klementowicz, Joanna E.
AU - Travis, Mark A.
N1 - Copyright © 2012 Elsevier GmbH. All rights reserved.
PY - 2012/12
Y1 - 2012/12
N2 - Regulation of an immune response requires complex crosstalk between cells of the innate and adaptive immune systems, via both cell-cell contact and secretion of cytokines. An important cytokine with a broad regulatory role in the immune system is transforming growth factor-β (TGF-β). TGF-β is produced by and has effects on many different cells of the immune system, and plays fundamental roles in the regulation of immune responses during homeostasis, infection and disease. Although many cells can produce TGFβ, it is always produced as an inactive complex that must be activated to bind to the TGFβ receptor complex and promote downstream signalling. Thus, regulation of TGFβ activation is a crucial step in controlling TGFβ function. This review will discuss how TGFβ controls diverse immune responses and how TGFβ function is regulated, with a focus on recent work highlighting a critical role for the integrin αvβ8 expressed by dendritic cells in activating TGFβ.
AB - Regulation of an immune response requires complex crosstalk between cells of the innate and adaptive immune systems, via both cell-cell contact and secretion of cytokines. An important cytokine with a broad regulatory role in the immune system is transforming growth factor-β (TGF-β). TGF-β is produced by and has effects on many different cells of the immune system, and plays fundamental roles in the regulation of immune responses during homeostasis, infection and disease. Although many cells can produce TGFβ, it is always produced as an inactive complex that must be activated to bind to the TGFβ receptor complex and promote downstream signalling. Thus, regulation of TGFβ activation is a crucial step in controlling TGFβ function. This review will discuss how TGFβ controls diverse immune responses and how TGFβ function is regulated, with a focus on recent work highlighting a critical role for the integrin αvβ8 expressed by dendritic cells in activating TGFβ.
KW - Animals
KW - Dendritic Cells
KW - Humans
KW - Immune System
KW - Integrins
KW - Transforming Growth Factor beta
U2 - 10.1016/j.imbio.2012.06.009
DO - 10.1016/j.imbio.2012.06.009
M3 - Journal article
C2 - 22902140
VL - 217
SP - 1259
EP - 1265
JO - Immunobiology
JF - Immunobiology
SN - 0171-2985
IS - 12
ER -