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Regulation of TGFβ in the immune system: an emerging role for integrins and dendritic cells

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Regulation of TGFβ in the immune system: an emerging role for integrins and dendritic cells. / Worthington, John J.; Fenton, Thomas M.; Czajkowska, Beata I. et al.
In: Immunobiology, Vol. 217, No. 12, 12.2012, p. 1259-1265.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Worthington, JJ, Fenton, TM, Czajkowska, BI, Klementowicz, JE & Travis, MA 2012, 'Regulation of TGFβ in the immune system: an emerging role for integrins and dendritic cells', Immunobiology, vol. 217, no. 12, pp. 1259-1265. https://doi.org/10.1016/j.imbio.2012.06.009

APA

Worthington, J. J., Fenton, T. M., Czajkowska, B. I., Klementowicz, J. E., & Travis, M. A. (2012). Regulation of TGFβ in the immune system: an emerging role for integrins and dendritic cells. Immunobiology, 217(12), 1259-1265. https://doi.org/10.1016/j.imbio.2012.06.009

Vancouver

Worthington JJ, Fenton TM, Czajkowska BI, Klementowicz JE, Travis MA. Regulation of TGFβ in the immune system: an emerging role for integrins and dendritic cells. Immunobiology. 2012 Dec;217(12):1259-1265. Epub 2012 Jul 2. doi: 10.1016/j.imbio.2012.06.009

Author

Worthington, John J. ; Fenton, Thomas M. ; Czajkowska, Beata I. et al. / Regulation of TGFβ in the immune system : an emerging role for integrins and dendritic cells. In: Immunobiology. 2012 ; Vol. 217, No. 12. pp. 1259-1265.

Bibtex

@article{a17dcc3275df4deeb2fecb23d394c3a6,
title = "Regulation of TGFβ in the immune system: an emerging role for integrins and dendritic cells",
abstract = "Regulation of an immune response requires complex crosstalk between cells of the innate and adaptive immune systems, via both cell-cell contact and secretion of cytokines. An important cytokine with a broad regulatory role in the immune system is transforming growth factor-β (TGF-β). TGF-β is produced by and has effects on many different cells of the immune system, and plays fundamental roles in the regulation of immune responses during homeostasis, infection and disease. Although many cells can produce TGFβ, it is always produced as an inactive complex that must be activated to bind to the TGFβ receptor complex and promote downstream signalling. Thus, regulation of TGFβ activation is a crucial step in controlling TGFβ function. This review will discuss how TGFβ controls diverse immune responses and how TGFβ function is regulated, with a focus on recent work highlighting a critical role for the integrin αvβ8 expressed by dendritic cells in activating TGFβ.",
keywords = "Animals, Dendritic Cells, Humans, Immune System, Integrins, Transforming Growth Factor beta",
author = "Worthington, {John J.} and Fenton, {Thomas M.} and Czajkowska, {Beata I.} and Klementowicz, {Joanna E.} and Travis, {Mark A.}",
note = "Copyright {\textcopyright} 2012 Elsevier GmbH. All rights reserved.",
year = "2012",
month = dec,
doi = "10.1016/j.imbio.2012.06.009",
language = "English",
volume = "217",
pages = "1259--1265",
journal = "Immunobiology",
issn = "0171-2985",
publisher = "Urban und Fischer Verlag GmbH und Co. KG",
number = "12",

}

RIS

TY - JOUR

T1 - Regulation of TGFβ in the immune system

T2 - an emerging role for integrins and dendritic cells

AU - Worthington, John J.

AU - Fenton, Thomas M.

AU - Czajkowska, Beata I.

AU - Klementowicz, Joanna E.

AU - Travis, Mark A.

N1 - Copyright © 2012 Elsevier GmbH. All rights reserved.

PY - 2012/12

Y1 - 2012/12

N2 - Regulation of an immune response requires complex crosstalk between cells of the innate and adaptive immune systems, via both cell-cell contact and secretion of cytokines. An important cytokine with a broad regulatory role in the immune system is transforming growth factor-β (TGF-β). TGF-β is produced by and has effects on many different cells of the immune system, and plays fundamental roles in the regulation of immune responses during homeostasis, infection and disease. Although many cells can produce TGFβ, it is always produced as an inactive complex that must be activated to bind to the TGFβ receptor complex and promote downstream signalling. Thus, regulation of TGFβ activation is a crucial step in controlling TGFβ function. This review will discuss how TGFβ controls diverse immune responses and how TGFβ function is regulated, with a focus on recent work highlighting a critical role for the integrin αvβ8 expressed by dendritic cells in activating TGFβ.

AB - Regulation of an immune response requires complex crosstalk between cells of the innate and adaptive immune systems, via both cell-cell contact and secretion of cytokines. An important cytokine with a broad regulatory role in the immune system is transforming growth factor-β (TGF-β). TGF-β is produced by and has effects on many different cells of the immune system, and plays fundamental roles in the regulation of immune responses during homeostasis, infection and disease. Although many cells can produce TGFβ, it is always produced as an inactive complex that must be activated to bind to the TGFβ receptor complex and promote downstream signalling. Thus, regulation of TGFβ activation is a crucial step in controlling TGFβ function. This review will discuss how TGFβ controls diverse immune responses and how TGFβ function is regulated, with a focus on recent work highlighting a critical role for the integrin αvβ8 expressed by dendritic cells in activating TGFβ.

KW - Animals

KW - Dendritic Cells

KW - Humans

KW - Immune System

KW - Integrins

KW - Transforming Growth Factor beta

U2 - 10.1016/j.imbio.2012.06.009

DO - 10.1016/j.imbio.2012.06.009

M3 - Journal article

C2 - 22902140

VL - 217

SP - 1259

EP - 1265

JO - Immunobiology

JF - Immunobiology

SN - 0171-2985

IS - 12

ER -