Rights statement: This is the peer reviewed version of the following article: Titman, A., Price, V., Hawcutt, D., Chesters, C., Ali, M., Cacace, G., Lancaster, G.A., Peak, M. and Blair, J.C. (2020), Salivary cortisol, cortisone and serum cortisol concentrations are related to age and body mass index in healthy children and young people. Clin Endocrinol. Accepted Author Manuscript. doi:10.1111/cen.14294 which has been published in final form at https://onlinelibrary.wiley.com/doi/10.1111/cen.14294 This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
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Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Salivary cortisol, cortisone and serum cortisol concentrations are related to age and body mass index in healthy children and young people
AU - Titman, Andrew
AU - Price, Victoria
AU - Hawcutt, Daniel
AU - Chesters, Chris
AU - Ali, Murtaza
AU - Cacace, Gianluca
AU - Lancaster, Gillian
AU - Peak, Matthew
AU - Blair, Joanne C
N1 - This is the peer reviewed version of the following article: Titman, A., Price, V., Hawcutt, D., Chesters, C., Ali, M., Cacace, G., Lancaster, G.A., Peak, M. and Blair, J.C. (2020), Salivary cortisol, cortisone and serum cortisol concentrations are related to age and body mass index in healthy children and young people. Clin Endocrinol. Accepted Author Manuscript. doi:10.1111/cen.14294 which has been published in final form at https://onlinelibrary.wiley.com/doi/10.1111/cen.14294 This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
PY - 2020/10/31
Y1 - 2020/10/31
N2 - Background: Saliva is an ideal medium in which to measure cortisol in children. However, there are very few data reporting salivary cortisol or cortisone concentrations in healthy children since the introduction of liquid chromatography-mass spectrometry (LC-MS/MS) to routine laboratory practice. Design: Early morning serum cortisol, salivary cortisol and cortisone were measured on fasting samples, and salivary hormones were measured in samples collected every 2 hours during waking hours, and 30 minutes after waking the following morning. Participants: 43 healthy paediatric volunteers (19 female), median age 11.5 years, range 6.2-18.7, participated. Results: Early morning serum cortisol (265 nmol/L, 156-516) correlated strongly with salivary cortisol (4.7 nmol/L, 1.1-14.6) and cortisone (28.8 nmol/L, 11.7-56.6), P <.0001 for both. Serum cortisol, salivary cortisol and salivary cortisone correlated directly with age (P <.0001, P =.002 and P =.015, respectively), and salivary cortisone/cortisol ratio correlated indirectly with age (P =.007). Between 08.00 and 21.00, area under the curve for salivary cortisol (mean ± 1 SD) was 41.8 ± 19.1 and for cortisone 213.0 ± 61.2. Salivary cortisol was undetectable in 25/130 (19%) of samples collected after 13.00, while cortisone was always detectable. Discussion: Salivary cortisol and cortisone concentrations are strongly related to serum cortisol concentrations; however, cortisone may be a preferable measure as cortisol is often undetectable. Age may be an important factor in the interpretation of early morning cortisol measurements made in serum and saliva.
AB - Background: Saliva is an ideal medium in which to measure cortisol in children. However, there are very few data reporting salivary cortisol or cortisone concentrations in healthy children since the introduction of liquid chromatography-mass spectrometry (LC-MS/MS) to routine laboratory practice. Design: Early morning serum cortisol, salivary cortisol and cortisone were measured on fasting samples, and salivary hormones were measured in samples collected every 2 hours during waking hours, and 30 minutes after waking the following morning. Participants: 43 healthy paediatric volunteers (19 female), median age 11.5 years, range 6.2-18.7, participated. Results: Early morning serum cortisol (265 nmol/L, 156-516) correlated strongly with salivary cortisol (4.7 nmol/L, 1.1-14.6) and cortisone (28.8 nmol/L, 11.7-56.6), P <.0001 for both. Serum cortisol, salivary cortisol and salivary cortisone correlated directly with age (P <.0001, P =.002 and P =.015, respectively), and salivary cortisone/cortisol ratio correlated indirectly with age (P =.007). Between 08.00 and 21.00, area under the curve for salivary cortisol (mean ± 1 SD) was 41.8 ± 19.1 and for cortisone 213.0 ± 61.2. Salivary cortisol was undetectable in 25/130 (19%) of samples collected after 13.00, while cortisone was always detectable. Discussion: Salivary cortisol and cortisone concentrations are strongly related to serum cortisol concentrations; however, cortisone may be a preferable measure as cortisol is often undetectable. Age may be an important factor in the interpretation of early morning cortisol measurements made in serum and saliva.
U2 - 10.1111/cen.14294
DO - 10.1111/cen.14294
M3 - Journal article
VL - 93
SP - 572
EP - 578
JO - Clinical Endocrinology
JF - Clinical Endocrinology
SN - 0300-0664
IS - 5
ER -