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Simultaneous optical coherence tomography and scheimpflug imaging using the same incident light

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Simultaneous optical coherence tomography and scheimpflug imaging using the same incident light. / Li, Xiaoran; Lawman, Samuel; Williams, Bryan M. et al.
In: Optics Express, Vol. 28, No. 26, 21.12.2020, p. 39660-39676.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Li, X, Lawman, S, Williams, BM, Ye, S, Shen, Y & Zheng, Y 2020, 'Simultaneous optical coherence tomography and scheimpflug imaging using the same incident light', Optics Express, vol. 28, no. 26, pp. 39660-39676. https://doi.org/10.1364/OE.405643

APA

Vancouver

Li X, Lawman S, Williams BM, Ye S, Shen Y, Zheng Y. Simultaneous optical coherence tomography and scheimpflug imaging using the same incident light. Optics Express. 2020 Dec 21;28(26):39660-39676. Epub 2020 Dec 16. doi: 10.1364/OE.405643

Author

Li, Xiaoran ; Lawman, Samuel ; Williams, Bryan M. et al. / Simultaneous optical coherence tomography and scheimpflug imaging using the same incident light. In: Optics Express. 2020 ; Vol. 28, No. 26. pp. 39660-39676.

Bibtex

@article{3fe5a4e5f323422ea1469dc78cf3e867,
title = "Simultaneous optical coherence tomography and scheimpflug imaging using the same incident light",
abstract = "For any single anterior chamber cross-sectional (tomographic) imaging method, there is a practical compromise between image size and image resolution. In order to obtain large field-of-view cross-sectional images of the whole anterior chamber and high-resolution cross-sectional images of the fine corneal layers, measurements by multiple devices are currently required. This paper presents a novel raster scanning tomographic imaging device that acquires simultaneous large field-of-view Scheimpflug (12.5 mm image depth, 50 µm axial resolution in air) and high-resolution spectral domain optical coherence tomography (SD-OCT) (2 mm image depth, 3.7µm axial resolution in air) using the same illuminating photons. For the novel raster scanning 3D Scheimpflug imaging, a tunable lens system together with numerical methods for correcting refraction distortion were used. To demonstrate the capability of simultaneous measurement of both fine corneal layers and whole anterior chambers topology, ex vivo measurements on 12 porcine and 12 bovine eyes were carried out. There is a reasonable agreement in the overall central corneal thicknesses (CCT) obtained from the simultaneous SD-OCT and Scheimpflug measurements. In addition, because the same infrared light beam was used to illuminate the sample, both OCT and Scheimpflug images were taken at the exact same location of a sample simultaneously in a single measurement. This provides a unique method for measuring both the thickness and the refractive index of a sample.",
author = "Xiaoran Li and Samuel Lawman and Williams, {Bryan M.} and Sicong Ye and Yaochun Shen and Yalin Zheng",
year = "2020",
month = dec,
day = "21",
doi = "10.1364/OE.405643",
language = "English",
volume = "28",
pages = "39660--39676",
journal = "Optics Express",
issn = "1094-4087",
publisher = "Optical Society of American (OSA)",
number = "26",

}

RIS

TY - JOUR

T1 - Simultaneous optical coherence tomography and scheimpflug imaging using the same incident light

AU - Li, Xiaoran

AU - Lawman, Samuel

AU - Williams, Bryan M.

AU - Ye, Sicong

AU - Shen, Yaochun

AU - Zheng, Yalin

PY - 2020/12/21

Y1 - 2020/12/21

N2 - For any single anterior chamber cross-sectional (tomographic) imaging method, there is a practical compromise between image size and image resolution. In order to obtain large field-of-view cross-sectional images of the whole anterior chamber and high-resolution cross-sectional images of the fine corneal layers, measurements by multiple devices are currently required. This paper presents a novel raster scanning tomographic imaging device that acquires simultaneous large field-of-view Scheimpflug (12.5 mm image depth, 50 µm axial resolution in air) and high-resolution spectral domain optical coherence tomography (SD-OCT) (2 mm image depth, 3.7µm axial resolution in air) using the same illuminating photons. For the novel raster scanning 3D Scheimpflug imaging, a tunable lens system together with numerical methods for correcting refraction distortion were used. To demonstrate the capability of simultaneous measurement of both fine corneal layers and whole anterior chambers topology, ex vivo measurements on 12 porcine and 12 bovine eyes were carried out. There is a reasonable agreement in the overall central corneal thicknesses (CCT) obtained from the simultaneous SD-OCT and Scheimpflug measurements. In addition, because the same infrared light beam was used to illuminate the sample, both OCT and Scheimpflug images were taken at the exact same location of a sample simultaneously in a single measurement. This provides a unique method for measuring both the thickness and the refractive index of a sample.

AB - For any single anterior chamber cross-sectional (tomographic) imaging method, there is a practical compromise between image size and image resolution. In order to obtain large field-of-view cross-sectional images of the whole anterior chamber and high-resolution cross-sectional images of the fine corneal layers, measurements by multiple devices are currently required. This paper presents a novel raster scanning tomographic imaging device that acquires simultaneous large field-of-view Scheimpflug (12.5 mm image depth, 50 µm axial resolution in air) and high-resolution spectral domain optical coherence tomography (SD-OCT) (2 mm image depth, 3.7µm axial resolution in air) using the same illuminating photons. For the novel raster scanning 3D Scheimpflug imaging, a tunable lens system together with numerical methods for correcting refraction distortion were used. To demonstrate the capability of simultaneous measurement of both fine corneal layers and whole anterior chambers topology, ex vivo measurements on 12 porcine and 12 bovine eyes were carried out. There is a reasonable agreement in the overall central corneal thicknesses (CCT) obtained from the simultaneous SD-OCT and Scheimpflug measurements. In addition, because the same infrared light beam was used to illuminate the sample, both OCT and Scheimpflug images were taken at the exact same location of a sample simultaneously in a single measurement. This provides a unique method for measuring both the thickness and the refractive index of a sample.

U2 - 10.1364/OE.405643

DO - 10.1364/OE.405643

M3 - Journal article

C2 - 33379511

AN - SCOPUS:85098725212

VL - 28

SP - 39660

EP - 39676

JO - Optics Express

JF - Optics Express

SN - 1094-4087

IS - 26

ER -