Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Article number | 123885 |
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<mark>Journal publication date</mark> | 1/02/2023 |
<mark>Journal</mark> | Talanta |
Volume | 253 |
Publication Status | Published |
Early online date | 28/08/22 |
<mark>Original language</mark> | English |
Endocrine-disrupting chemicals (EDC) are pollutants that alter the function of the endocrine system by interfering with hormone biosynthesis, metabolism, or action. In this study, a spectroscopic ellipsometry platform is proposed using aptamers for the sensitive and selective detection of an EDC, 2,2-Bis(4-hydroxyphenyl)propane (Bisphenol A, BPA). Two different BPA-specific aptamers (Anti-BPA1 and Anti-BPA2) were immobilized to silicon wafer chips by the layer-by-layer self-assembly, a detection limit of 215 pM and 36 pM was obtained using the ellipsometric method for Anti-BPA1 and Anti-BPA2, respectively. Sensor specificity was tested with 2,2-Bis(4-hydroxyphenyl)butane and a maximum RSD of 3.8% was obtained. It has been reported that both aptasensors based on spectroscopic ellipsometry exhibit adequate analytical performance.