Home > Research > Publications & Outputs > Spectroscopic ellipsometry-based aptasensor pla...


Text available via DOI:

View graph of relations

Spectroscopic ellipsometry-based aptasensor platform for bisphenol a detection

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Article number123885
<mark>Journal publication date</mark>1/02/2023
Publication StatusPublished
Early online date28/08/22
<mark>Original language</mark>English


Endocrine-disrupting chemicals (EDC) are pollutants that alter the function of the endocrine system by interfering with hormone biosynthesis, metabolism, or action. In this study, a spectroscopic ellipsometry platform is proposed using aptamers for the sensitive and selective detection of an EDC, 2,2-Bis(4-hydroxyphenyl)propane (Bisphenol A, BPA). Two different BPA-specific aptamers (Anti-BPA1 and Anti-BPA2) were immobilized to silicon wafer chips by the layer-by-layer self-assembly, a detection limit of 215 pM and 36 pM was obtained using the ellipsometric method for Anti-BPA1 and Anti-BPA2, respectively. Sensor specificity was tested with 2,2-Bis(4-hydroxyphenyl)butane and a maximum RSD of 3.8% was obtained. It has been reported that both aptasensors based on spectroscopic ellipsometry exhibit adequate analytical performance.